BRIEF REPORT: CHEMOPROTECTIVE EFFECTS OF MYRISTIN AGAINST GENOTOXICITY INDUCED BY ENDOSULFAN ON HUMAN BLOOD LYMPHOCYTE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHOKRZADEH MOHAMMAD; HABIBI EMRAN; ZAMANI ANAHITA; MODANLOO MONA; ALIZADEH MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:26 | Issue:141 Page(s): 143-148

Download Full-Text

Persian Verion

View:

768

Download:

Cites:

Information Journal Paper

Title

BRIEF REPORT: CHEMOPROTECTIVE EFFECTS OF MYRISTIN AGAINST GENOTOXICITY INDUCED BY ENDOSULFAN ON HUMAN BLOOD LYMPHOCYTE

Author(s)

Keywords

ENDOSULFANQ2

MYRISTINQ1

GENOTOXICITYQ1

HUMAN LYMPHOCYTEQ1

MICRONUCLEUS TESTQ1

Abstract

Background and purpose: Myricetin as a natural flavonoids in tea and coffee, has extensive pharmacological effects. ENDOSULFAN is mutagenic and is capable of inducing genetic damage in human blood cells. The aim of this study was to investigate the protective effect of myricetin against DNA damage caused by ENDOSULFAN on human blood lymphocytes.Materials and methods: Blood samples after 3 hours of incubation with different concentrations of myricetin, were incubated with Mm10 ENDOSULFAN for 24 hours. Then, to evaluate the production of micronucleus in binucleated lymphocytes, the slides were prepared and were evaluated by light microscopy. The mean values were compared using PRISM and ANOVA (posttest: Tukey).Results: The incubation of blood samples with ENDOSULFAN induced additional GENOTOXICITY in lymphocytes, and MYRISTIN pretreatment significantly reduced the micronucleus frequency (P<0.01). The results showed the effective role of MYRISTIN as protective agent in reducing the GENOTOXICITY of the pesticide ENDOSULFAN.Conclusion: MYRISTIN appeared to scavenge and trap free radicals to prevent the damage induced by ROS. It is a natural compound and is considered to be safe, therefore, it can be used as a supplement to protect people exposed to chemical or environmental hazards.

Cites

No record.

References

No record.

Cite

APA: Copy

SHOKRZADEH, MOHAMMAD, HABIBI, EMRAN, ZAMANI, ANAHITA, MODANLOO, MONA, & ALIZADEH, MARYAM. (2016). BRIEF REPORT: CHEMOPROTECTIVE EFFECTS OF MYRISTIN AGAINST GENOTOXICITY INDUCED BY ENDOSULFAN ON HUMAN BLOOD LYMPHOCYTE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(141), 143-148. SID. https://sid.ir/paper/45611/en

Vancouver: Copy

SHOKRZADEH MOHAMMAD, HABIBI EMRAN, ZAMANI ANAHITA, MODANLOO MONA, ALIZADEH MARYAM. BRIEF REPORT: CHEMOPROTECTIVE EFFECTS OF MYRISTIN AGAINST GENOTOXICITY INDUCED BY ENDOSULFAN ON HUMAN BLOOD LYMPHOCYTE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(141):143-148. Available from: https://sid.ir/paper/45611/en

IEEE: Copy

MOHAMMAD SHOKRZADEH, EMRAN HABIBI, ANAHITA ZAMANI, MONA MODANLOO, and MARYAM ALIZADEH, “BRIEF REPORT: CHEMOPROTECTIVE EFFECTS OF MYRISTIN AGAINST GENOTOXICITY INDUCED BY ENDOSULFAN ON HUMAN BLOOD LYMPHOCYTE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 141, pp. 143–148, 2016, [Online]. Available: https://sid.ir/paper/45611/en

Related Journal Papers