EFFECT OF NERVE GROWTH FACTOR ON ANXIETY-LIKE BEHAVIORS INDUCED BY FORCED SWIM STRESS IN RATS

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AZHDARI ZARMEHRI HASSAN; KHOSRAVI HOSEIN; Mohebi Ehsan; MOJADADI MOHAMMAD SHAFI; MOHAMMADZADEH MOHAMMAD

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Title

EFFECT OF NERVE GROWTH FACTOR ON ANXIETY-LIKE BEHAVIORS INDUCED BY FORCED SWIM STRESS IN RATS

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Keywords

NERVE GROWTH FACTOR INHIBITORQ1

FORCED SWIM STRESSQ1

ANXIETY-LIKE BEHAVIORSQ1

ELEVATED PLUS MAZEQ1

Abstract

Background and purpose: Nerve growth factor (NGF), as neurotrophin, has a role in response of hypothalamic-pituitary-adrenal axis to stress. In this study, we investigated the role of NGF by inhibiting nerve growth factor ANXIETY-LIKE BEHAVIORS induced by FORCED SWIM STRESS in rats.Materials and methods: In this experimental study, 24 male Wistar rats (200-250 g) were randomly divided into four groups (Control group: vehicle group and treatment groups: 10, 50 and 100 mM of AVG 879 tyrphostin). Intraventricular injection of vehicle and AVG 879 is exerted before force swim stress. Morris water Maze was used to investigate anxiety levels. Data was analyzed by STATISTICA V 5.5 usig ANOVA test.Results: The duration time in closing arm reduced in the group that received AG-879 at low concentrations (10 and 50 mM) (P< 0.05), while it increased in the group that received Tyrphostin at 100 mM (P<0.05). Also, the time duration in the open arm significantly increased in rats that had AG- 79 at 10 and 50 mM, but at 100 mM of the drug this parameter decreased (P<0.05).Conclusion: Exposure to stress increased anxiety-related behavior. Compared with the control group, ANXIETY-LIKE BEHAVIORS reduced in the groups that received NERVE GROWTH FACTOR INHIBITOR.

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APA: Copy

AZHDARI ZARMEHRI, HASSAN, KHOSRAVI, HOSEIN, Mohebi, Ehsan, MOJADADI, MOHAMMAD SHAFI, & MOHAMMADZADEH, MOHAMMAD. (2017). EFFECT OF NERVE GROWTH FACTOR ON ANXIETY-LIKE BEHAVIORS INDUCED BY FORCED SWIM STRESS IN RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(145), 186-198. SID. https://sid.ir/paper/45788/en

Vancouver: Copy

AZHDARI ZARMEHRI HASSAN, KHOSRAVI HOSEIN, Mohebi Ehsan, MOJADADI MOHAMMAD SHAFI, MOHAMMADZADEH MOHAMMAD. EFFECT OF NERVE GROWTH FACTOR ON ANXIETY-LIKE BEHAVIORS INDUCED BY FORCED SWIM STRESS IN RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;26(145):186-198. Available from: https://sid.ir/paper/45788/en

IEEE: Copy

HASSAN AZHDARI ZARMEHRI, HOSEIN KHOSRAVI, Ehsan Mohebi, MOHAMMAD SHAFI MOJADADI, and MOHAMMAD MOHAMMADZADEH, “EFFECT OF NERVE GROWTH FACTOR ON ANXIETY-LIKE BEHAVIORS INDUCED BY FORCED SWIM STRESS IN RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 145, pp. 186–198, 2017, [Online]. Available: https://sid.ir/paper/45788/en

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