THE HEPATOTOXIC EFFECTS OF STACHYS LAVANDULIFOLIA VAHL ON WISTAR RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAGHIKHANI AFSHIN; ANSARISAMANI ROYA; AFROGH HAMID; SHAHINFARD NAJMEH; GANJI FOROUZAN; ASGARI AZAM; TAJI FATEMEH; EBRAHIMI MARZIEH; ASGHARZADEH SAMIRA; RAFIEIAN KOPAEI MAHMOUD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:22 | Issue:88 Page(s): 81-87

Download Full-Text

Persian Verion

View:

931

Download:

Cites:

Information Journal Paper

Title

THE HEPATOTOXIC EFFECTS OF STACHYS LAVANDULIFOLIA VAHL ON WISTAR RAT

Author(s)

Keywords

WISTAR RATQ2

TOXICITYQ2

STACHYS LAVANDULIFOLIA VAHLQ2

ALCOHOLIC EXTRACTQ2

Abstract

Background and purpose: Stachys lavandulifolia is a plant commonly used for many diseases. But so far there is no report indicating its TOXICITY. The aim of this study was to investigate the probable hepatoxicity of S. lavandulifolia extract on WISTAR RATs.Materials and methods: In this experimental study, 100 WISTAR RATs (about 250 gr, 8-12 weeks old) were randomly divided into 10 groups (8 groups as case and 2 groups as control). They were intraperitoneally injected with S. lavandulifolia extract with doses of 50, 100, 150 and 200 mg/kg per day for 28 days. Afterwards, the serum parameters level (ALP, AST, ALT) and pathological samples were evaluated and compared in four case group and one control group after 28 days and other groups after one month.Results: On the first month there was significant increase on AST level only in 200 mg/kg dose while ALP level significantly increased in all doses (P<0.05). There was no significant difference among all doses regarding their effects on the increase of liver enzymes (P>0.05). On the second month, the changes in liver enzymes were almost the same as first month, except 150 mg/kg dose that significantly increased the AST level compared to control group and also this dose significantly increased the ALP level compared to 100mg/kg dose (P<0.05). In examining liver samples obtained from rats in the first and second months, necrotic inflammatory reactions and fibrotic lesions significantly increased compared to control group (P<0.001). In the first month we also found that there was significant difference between higher doses (150 and 200 mg/kg) and lower doses (50 and 100 mg/kg) regarding their effects on hepatic lesion (P<0.05).Conclusion: Since the extract of S. lavandulifolia causes TOXICITY it should be consumed with caution in people with underlying cholestatic diseases.

Cites

EVALUATION THE ROLE OF FERULA GUMMOSA ESSENTIAL OIL AGAINST THE HEPATOXICITY INDUCED BY ACETAMINOPHEN IN ANIMAL MODEL

References

No record.

Cite

APA: Copy

TAGHIKHANI, AFSHIN, ANSARISAMANI, ROYA, AFROGH, HAMID, SHAHINFARD, NAJMEH, GANJI, FOROUZAN, ASGARI, AZAM, TAJI, FATEMEH, EBRAHIMI, MARZIEH, ASGHARZADEH, SAMIRA, & RAFIEIAN KOPAEI, MAHMOUD. (2012). THE HEPATOTOXIC EFFECTS OF STACHYS LAVANDULIFOLIA VAHL ON WISTAR RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(88), 81-87. SID. https://sid.ir/paper/45838/en

Vancouver: Copy

TAGHIKHANI AFSHIN, ANSARISAMANI ROYA, AFROGH HAMID, SHAHINFARD NAJMEH, GANJI FOROUZAN, ASGARI AZAM, TAJI FATEMEH, EBRAHIMI MARZIEH, ASGHARZADEH SAMIRA, RAFIEIAN KOPAEI MAHMOUD. THE HEPATOTOXIC EFFECTS OF STACHYS LAVANDULIFOLIA VAHL ON WISTAR RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(88):81-87. Available from: https://sid.ir/paper/45838/en

IEEE: Copy

AFSHIN TAGHIKHANI, ROYA ANSARISAMANI, HAMID AFROGH, NAJMEH SHAHINFARD, FOROUZAN GANJI, AZAM ASGARI, FATEMEH TAJI, MARZIEH EBRAHIMI, SAMIRA ASGHARZADEH, and MAHMOUD RAFIEIAN KOPAEI, “THE HEPATOTOXIC EFFECTS OF STACHYS LAVANDULIFOLIA VAHL ON WISTAR RAT,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 88, pp. 81–87, 2012, [Online]. Available: https://sid.ir/paper/45838/en

Related Journal Papers