THE EFFECT OF L-NAME ON MORPHINE ANTINOCICEPTION IN FORMALIN TEST

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MOKHTARI M.; SHARIATIE M.; REZAEIAN L.

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Journal: Journal of Kerman University of Medical Sciences Year:2006 | Volume:13 | Issue:1 Page(s): 29-36

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Title

THE EFFECT OF L-NAME ON MORPHINE ANTINOCICEPTION IN FORMALIN TEST

Author(s)

MOKHTARI M. | SHARIATIE M. | REZAEIAN L. | Issue Writer Certificate

Keywords

L-NAMEQ2

MORPHINEQ3

ANTINOCICEPTIONQ3

FORMALIN TESTQ3

Abstract

Introduction: N- nitro-L-arginine methyl ester (L-NAME), one of the L-arginine analogs, has been specified as an inhibitor of nitric oxide synthase (NOS).Nitric oxide synthase is an enzyme which leads to nitric oxide synthesis. Since nitric oxide has been known as a pain mediator, it can be said that L-NAME can decrease and relieve pain. In this research the effect of L-NAME on MORPHINE ANTINOCICEPTION and the interaction between these two drugs were studied by using FORMALIN TEST in rat.Methods: Experiments were done on 70 male-wistar rats weighing 180-230gr. Rats were divided into seven groups (n =10) including: the control group, the saline group(sham), the experimental group receiving 2mg/kg of MORPHINE, and the experimental groups receiving 15, 20, 40mg/kg L-NAME and MORPHINE (2mg/Rat), and the group receiving 40 mg/kg of L-NAME. Injections were performed intraperitoneally fifteen minutes before starting FORMALIN TEST. In sham group, an equal volume of normal saline was injected intraperitoneally. The minutes (0-5) and (16-60) were respectively considered as acute and chronic phases of pain in the FORMALIN TEST. After observing animals’ behavioral responses and calculating pain scores, groups were compared.Results: According to the obtained results, L-NAME caused a significant nociception decrease in both phases of FORMALIN TEST and this effect was dose dependent. Moreover groups that received the combination of MORPHINE and L-NAME showed more nocieception, especially in chronic phase of FORMALIN TEST, in comparison to the groups that received each in isolatin and control groups (P<0.05).Conclusion: According to the results, L-NAME and MORPHINE act synergistically. In other words, L-NAME with nitric oxide inhibitor decreases intracell signal activities of cGMP and CAMP and consequently protein Kinase A (PKA) activity related to cAMP is decreased. This leads to an increase in the releasing of neurotransmitters related to PKA, and consequently MORPHINE antinociceptive effect is amplified.

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APA: Copy

MOKHTARI, M., SHARIATIE, M., & REZAEIAN, L.. (2006). THE EFFECT OF L-NAME ON MORPHINE ANTINOCICEPTION IN FORMALIN TEST. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 13(1), 29-36. SID. https://sid.ir/paper/46/en

Vancouver: Copy

MOKHTARI M., SHARIATIE M., REZAEIAN L.. THE EFFECT OF L-NAME ON MORPHINE ANTINOCICEPTION IN FORMALIN TEST. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;13(1):29-36. Available from: https://sid.ir/paper/46/en

IEEE: Copy

M. MOKHTARI, M. SHARIATIE, and L. REZAEIAN, “THE EFFECT OF L-NAME ON MORPHINE ANTINOCICEPTION IN FORMALIN TEST,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 1, pp. 29–36, 2006, [Online]. Available: https://sid.ir/paper/46/en

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