PROTECTIVE EFFECT OF ATORVASTATIN AGAINST CARDIOTOXICITY AND HEMATOTOXICITY INDUCED BY CYCLOPHOSPHAMIDE IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAMZEH MAEDEH; TALEBPOUR AMIRI FERESHTEH; KARIMPOUR MALEKSHAH ABBASALI; YAGHUBI BEKLAR SAEED; HOSSEINIMEHR SEYED JALAL

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2017 | Volume:27 | Issue:151 Page(s): 1-11

Download Full-Text

Persian Verion

View:

758

Download:

Cites:

Information Journal Paper

Title

PROTECTIVE EFFECT OF ATORVASTATIN AGAINST CARDIOTOXICITY AND HEMATOTOXICITY INDUCED BY CYCLOPHOSPHAMIDE IN RAT

Author(s)

Keywords

CYCLOPHOSPHAMIDEQ1

CARDIOTOXICITYQ2

HEMATOXICITYQ1

ATORVASTATINQ2

ANTIOXIDANTQ2

Abstract

Background and purpose: CYCLOPHOSPHAMIDE (CP) is used as an anti-cancer and immunosuppressive agent and it is accompanied with severe CARDIOTOXICITY and anemia. ATORVASTATIN (ATV) is a widely used medication in hypercholesterolemia that has ANTIOXIDANT and anti-inflammatory properties at low dose. The aim of this study was to investigate the protective effect of ATV on CYCLOPHOSPHAMIDE-induced CARDIOTOXICITY and hematotoxicity in rats.Materials and methods: Thirty two rats were randomly divided into four groups as following: control group that received normal saline; CP group that received CP intraperitonealy single dose (150 mg/kg); the ATV group that were treated through gavage (10 mg/kg) for 10 days; and ATV + CP that received ATV five days before and five days after CP treatment. The animals were killed three days after the last treatment.Results: Administration of CP caused heart damage through increased activity of cardiac marker enzymes, such as CK-MB and LDH. Histological evaluation of heart tissue showed interstitial edema, necrosis, hemorrhage, congestion, and vacuole around the nucleus. The number of red and white blood cells, platelets, hemoglobin and hematocrit significantly decreased in the group that received CP. ATV significantly reduced the amount of oxidative stress enzymatic activity and heart tissue damage and preserved blood cell counts induced by CP.Conclusion: These findings prove the protective role of ATV on CP-induced CARDIOTOXICITY and hematotoxicity in mice.

Cites

Atorvastatin attenuates the ovarian damage induced by cyclophosphamide in rat: An experimental study

References

Cite

APA: Copy

HAMZEH, MAEDEH, TALEBPOUR AMIRI, FERESHTEH, KARIMPOUR MALEKSHAH, ABBASALI, YAGHUBI BEKLAR, SAEED, & HOSSEINIMEHR, SEYED JALAL. (2017). PROTECTIVE EFFECT OF ATORVASTATIN AGAINST CARDIOTOXICITY AND HEMATOTOXICITY INDUCED BY CYCLOPHOSPHAMIDE IN RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(151), 1-11. SID. https://sid.ir/paper/46060/en

Vancouver: Copy

HAMZEH MAEDEH, TALEBPOUR AMIRI FERESHTEH, KARIMPOUR MALEKSHAH ABBASALI, YAGHUBI BEKLAR SAEED, HOSSEINIMEHR SEYED JALAL. PROTECTIVE EFFECT OF ATORVASTATIN AGAINST CARDIOTOXICITY AND HEMATOTOXICITY INDUCED BY CYCLOPHOSPHAMIDE IN RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;27(151):1-11. Available from: https://sid.ir/paper/46060/en

IEEE: Copy

MAEDEH HAMZEH, FERESHTEH TALEBPOUR AMIRI, ABBASALI KARIMPOUR MALEKSHAH, SAEED YAGHUBI BEKLAR, and SEYED JALAL HOSSEINIMEHR, “PROTECTIVE EFFECT OF ATORVASTATIN AGAINST CARDIOTOXICITY AND HEMATOTOXICITY INDUCED BY CYCLOPHOSPHAMIDE IN RAT,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 151, pp. 1–11, 2017, [Online]. Available: https://sid.ir/paper/46060/en

Related Journal Papers