THE EFFECT OF ATORVASTATIN ON THE PANCREATIC TISSUE OF MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KARIMIAN M.; POURAHMADI M.; JELODAR G.A.; MEHRABI F.; MOHAMMADI Z.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Armaghane Danesh Year:2013 | Volume:18 | Issue:1 (73) Page(s): 44-49

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

948

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF ATORVASTATIN ON THE PANCREATIC TISSUE OF MALE RATS

Author(s)

Keywords

ATORVASTATINQ2

PANCREASQ2

RATQ2

Abstract

Background & aim: Statins are inhibitors drugs of hydroxymethyl glotaryl coenzyme A.In addition to decreasing plasma cholesterol, low-density cholesterol they reduce the RATe of triglycerides. The aim of this study was to investigate the effect of ATORVASTATIN on RAT pancreatic tissue. In addition to decreasing the RATe of plasma cholesterol concentration; they also decrease the RATe of LDL and Triglyceride. The aim of this study was to investigate the effect of ATORVASTATIN on RAT pancreatic tissue.Methods: In this study, 32 adult male RATs were divided into four groups, control and three test groups. To conduct the present study, 32 male adult RATs were divided into 4 equal groups: one control group and three test groups. Then the test groups were treated by ATORVASTATIN for 45 days with 10mg (group1), 20mg (group2) and 30 mg (group3) doses respectively. At the end of the treatment period, all RATs were killed by taking blood from their hearts. The PANCREAS tissue of each RAT (N=32) was separated. After fixation, tissue preparation and slide staining, Longerhans diameter was measured and number of cells was counted. Data were analyzed by t test. After fixing and coloring the tissue, all slides were prepared and evaluated under the microscope the diameter of I's of Longerhans and the number of cells. The data was analyzed through t-test.Results: There was no significant difference in the diameter mean of Longerhans between the test groups and the control group. The mean number of islets cells were increased in compared to the control group (P>0.05).There was also a significant increase was shown in the number of Longerhans cells in the test groups in relation to the control group (p<0.05).Conclusion: The consumption of the ATORVASTATINe causes an increase in the number of Longerhans cells. In addition, the increase in the number of cells also increases the insulin secretion. As a result, blood sugar is decreased.

Cites

No record.

References

Cite

APA: Copy

KARIMIAN, M., POURAHMADI, M., JELODAR, G.A., MEHRABI, F., & MOHAMMADI, Z.. (2013). THE EFFECT OF ATORVASTATIN ON THE PANCREATIC TISSUE OF MALE RATS. ARMAGHAN DANESH, 18(1 (73)), 44-49. SID. https://sid.ir/paper/77555/en

Vancouver: Copy

KARIMIAN M., POURAHMADI M., JELODAR G.A., MEHRABI F., MOHAMMADI Z.. THE EFFECT OF ATORVASTATIN ON THE PANCREATIC TISSUE OF MALE RATS. ARMAGHAN DANESH[Internet]. 2013;18(1 (73)):44-49. Available from: https://sid.ir/paper/77555/en

IEEE: Copy

M. KARIMIAN, M. POURAHMADI, G.A. JELODAR, F. MEHRABI, and Z. MOHAMMADI, “THE EFFECT OF ATORVASTATIN ON THE PANCREATIC TISSUE OF MALE RATS,” ARMAGHAN DANESH, vol. 18, no. 1 (73), pp. 44–49, 2013, [Online]. Available: https://sid.ir/paper/77555/en

Related Journal Papers