Anticancer Effects of Senecionine and Senecio vulgaris L. on Prostate Cancer Cell Lines

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MAHDAVI MORTEZA; AZADBAKHT MOHAMMAD; VAHDATI AKBAR; SHOKRZADEH MOHAMMAD; Farhadi Ayub; DAVOODI ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:28 | Issue:169 Page(s): 1-13

Download Full-Text

Persian Verion

View:

918

Download:

Cites:

Information Journal Paper

Title

Anticancer Effects of Senecionine and Senecio vulgaris L. on Prostate Cancer Cell Lines

Author(s)

Keywords

senecionineQ1

cancerQ2

cytotoxicQ2

apoptosisQ1

Abstract

Background and purpose This research aimed at evaluating the effects of senecionine and Senecio vulgaris extract on apoptosis and cell cycle inhibition. Also, their cytotoxicity on prostate cancer cell lines (PC3, DU145 and HGFs), antioxidant effects, and influences on AR and CLU gene expression were investigated. Materials and methods In this experimental study, senecionine and S. vulgaris extract were prepared and the induced morphological changes on cell lines were evaluated in DMEM F12 cell culture after 24, 48, 72, and 96 hours by an invert microscope. Then, cell viability and apoptosis were determined by MTT and fluorescence analysis, respectively. Finally, AR and CLU gene expression and methylation of AR gene were evaluated using Real-time PCR and Bi-Sulfide test, respectively. Results cytotoxicity data showed morphological changes 24 hours after treatment with senecionine in all cell lines and all concentrations which also increased in longer time. Based on MTT results, senecionine showed cytotoxicity in 50 and 500 μ g/ml on PC3 and du145 prostate cancer cell lines. Conclusion According to current findings, Ragwort aerial part extract are suggested for in vivo studies with minimum destruction on normal cells and inducing effects on destruction and apoptosis of prostate carcinogenic cell lines.

Cites

No record.

References

No record.

Cite

APA: Copy

MAHDAVI, MORTEZA, AZADBAKHT, MOHAMMAD, VAHDATI, AKBAR, SHOKRZADEH, MOHAMMAD, Farhadi, Ayub, & DAVOODI, ALI. (2019). Anticancer Effects of Senecionine and Senecio vulgaris L. on Prostate Cancer Cell Lines. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(169 ), 1-13. SID. https://sid.ir/paper/46105/en

Vancouver: Copy

MAHDAVI MORTEZA, AZADBAKHT MOHAMMAD, VAHDATI AKBAR, SHOKRZADEH MOHAMMAD, Farhadi Ayub, DAVOODI ALI. Anticancer Effects of Senecionine and Senecio vulgaris L. on Prostate Cancer Cell Lines. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;28(169 ):1-13. Available from: https://sid.ir/paper/46105/en

IEEE: Copy

MORTEZA MAHDAVI, MOHAMMAD AZADBAKHT, AKBAR VAHDATI, MOHAMMAD SHOKRZADEH, Ayub Farhadi, and ALI DAVOODI, “Anticancer Effects of Senecionine and Senecio vulgaris L. on Prostate Cancer Cell Lines,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 169 , pp. 1–13, 2019, [Online]. Available: https://sid.ir/paper/46105/en

Related Journal Papers