DETERMINATION OF SERUM PARAOXONASE (PON1) PHENOTYPE DISTRIBUTION BY DOUBLE-SUBSTRATE METHOD IN CORONARY ARTERY DISEASE (CAD)

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MAHROOZ ABDOLKARIM; NOURI MOHAMMAD; RASHIDI MOHAMMAD REZA; ASLANABADI NASER; QUJEQ D.

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2010 | Volume:32 | Issue:3 Page(s): 76-80

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Title

DETERMINATION OF SERUM PARAOXONASE (PON1) PHENOTYPE DISTRIBUTION BY DOUBLE-SUBSTRATE METHOD IN CORONARY ARTERY DISEASE (CAD)

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Keywords

PON1 PHENOTYPESQ3

PARAOXONASEQ2

ARYLESTERASEQ2

CORONARY STENOSISQ2

Abstract

Background and Objectives: Serum PARAOXONASE (PON1) is a high-density lipoprotein (HDL) -associated esterase that can prevent the formation of oxidized low-density lipoprotein (ox-LDL). PON1 activity is reduced in cardiovascular diseases. In the present study, distribution of PON1 PHENOTYPES in patients with coronary artery disease (CAD) was determined. Also, as studies on the association between PON1 activity and the extent of CORONARY STENOSIS are limited, the relationship between PARAOXONASE and aryl esterase activities of PON1 with extent of CORONARY STENOSIS has been investigated.Materials and Methods: Sixty one patients with CORONARY STENOSIS of < 50% and sixty three patients with CORONARY STENOSIS of > 70% were included in this study. PARAOXONASE and aryl esterase activities were measured using paraoxon and phenyl acetate as substrates, respectively. Phenotyping of the PON1 Q192R polymorphism was determined by double substrate method.Results: In patients with stenosis of < 50%, 41%, 46% and 13% of the patients belonged to phenotypes of Q, QR and R, respectively. The corresponding values in patients with stenosis of > 70% were 48%, 41% and 11%, respectively. Patients with stenosis of < 50% had significantly higher PARAOXONASE and aryl esterase activities (P=0.02 and P=0.04, respectively) compared to those with stenosis of > 70%. The levels of HDL-C in patients with stenosis of < 50% were significantly higher than those of > 70% stenosis group (P=0.025).Conclusion: In the present study, phenotype distribution of PON1 in subjects with CAD was determined. Also, there were significant differences in PARAOXONASE and aryl esterase activities and also HDL-C levels between patients with CORONARY STENOSIS of < 50% and those with CORONARY STENOSIS of > 70%. Therefore, this study provides further support for the important role of PARAOXONASE activity in coronary atherosclerosis.

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APA: Copy

MAHROOZ, ABDOLKARIM, NOURI, MOHAMMAD, RASHIDI, MOHAMMAD REZA, ASLANABADI, NASER, & QUJEQ, D.. (2010). DETERMINATION OF SERUM PARAOXONASE (PON1) PHENOTYPE DISTRIBUTION BY DOUBLE-SUBSTRATE METHOD IN CORONARY ARTERY DISEASE (CAD). MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 32(3), 76-80. SID. https://sid.ir/paper/46489/en

Vancouver: Copy

MAHROOZ ABDOLKARIM, NOURI MOHAMMAD, RASHIDI MOHAMMAD REZA, ASLANABADI NASER, QUJEQ D.. DETERMINATION OF SERUM PARAOXONASE (PON1) PHENOTYPE DISTRIBUTION BY DOUBLE-SUBSTRATE METHOD IN CORONARY ARTERY DISEASE (CAD). MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;32(3):76-80. Available from: https://sid.ir/paper/46489/en

IEEE: Copy

ABDOLKARIM MAHROOZ, MOHAMMAD NOURI, MOHAMMAD REZA RASHIDI, NASER ASLANABADI, and D. QUJEQ, “DETERMINATION OF SERUM PARAOXONASE (PON1) PHENOTYPE DISTRIBUTION BY DOUBLE-SUBSTRATE METHOD IN CORONARY ARTERY DISEASE (CAD),” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 32, no. 3, pp. 76–80, 2010, [Online]. Available: https://sid.ir/paper/46489/en

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