THE ACUTE AND CHRONIC EFFECTS OF METFORMIN ON MEMORY RETRIEVAL AND HIPPOCAMPALCA1 AREA INTACT NEURONS IN STREPTOZOTOCIN-INDUCED ALZHEIMERIC MALE RATS

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Darbandi Niloufar; MOGHADASI SAMIRA; MOMENI HAMID REZA

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2019 | Volume:40 | Issue:5 Page(s): 39-47

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Title

THE ACUTE AND CHRONIC EFFECTS OF METFORMIN ON MEMORY RETRIEVAL AND HIPPOCAMPALCA1 AREA INTACT NEURONS IN STREPTOZOTOCIN-INDUCED ALZHEIMERIC MALE RATS

Author(s)

Darbandi Niloufar | MOGHADASI SAMIRA | MOMENI HAMID REZA | Issue Writer Certificate

Keywords

METFORMINQ2

STREPTOZOTOCINQ2

MEMORYQ2

HIPPOCAMPUSQ2

Abstract

Background: In this study, both acute and chronic therapeutic effects of METFORMIN on MEMORY retrieval and thenumber of intact neurons of hippocampal CA1 area in STREPTOZOTOCIN-induced Alzheimeric male rats wereinvestigated. Methods: 48 Male Wistar rats weighing 220-250 g were divided into six groups: control group (saline-saline), STREPTOZOTOCIN group (streptozotocine-saline), treated groups with STREPTOZOTOCIN plus METFORMIN for once, one week, three weeks, and eleven weeks. ICV administration of STZ (3mg/kg) was down in the first and the third day ofsurgery and i. p injection of METFORMIN (200mg/kg) or saline (ml/kg) daily starting one day before surgery to the endof care period. After the MEMORY test, the animals were killed and their brains were fixed and density of intactneurons in the CA1 area of the HIPPOCAMPUS was investigated. Statistical analysis was performed with softwareSPSS, ANOVA and software Prisme. Results: The ICV injections of STZ significantly reduced MEMORY retention and the number of intact neuronscompared to the control group (p<0/001). The use of METFORMIN in once, one week and three weeks improved theeffects of STZ (p<0/001). But METFORMIN in eleven weeks treatment period don’ t have significant effect on MEMORYretrieval and the number of intact neurons in hippocampal CA1 area compared to the STZ group (p>0/05). Conclusion: Both acute and chronic METFORMIN uses have different effects on MEMORY retrieval and thenumber of intact hippocampal CA1 area neurons.

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APA: Copy

Darbandi, Niloufar, MOGHADASI, SAMIRA, & MOMENI, HAMID REZA. (2019). THE ACUTE AND CHRONIC EFFECTS OF METFORMIN ON MEMORY RETRIEVAL AND HIPPOCAMPALCA1 AREA INTACT NEURONS IN STREPTOZOTOCIN-INDUCED ALZHEIMERIC MALE RATS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 40(5 ), 39-47. SID. https://sid.ir/paper/46528/en

Vancouver: Copy

Darbandi Niloufar, MOGHADASI SAMIRA, MOMENI HAMID REZA. THE ACUTE AND CHRONIC EFFECTS OF METFORMIN ON MEMORY RETRIEVAL AND HIPPOCAMPALCA1 AREA INTACT NEURONS IN STREPTOZOTOCIN-INDUCED ALZHEIMERIC MALE RATS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;40(5 ):39-47. Available from: https://sid.ir/paper/46528/en

IEEE: Copy

Niloufar Darbandi, SAMIRA MOGHADASI, and HAMID REZA MOMENI, “THE ACUTE AND CHRONIC EFFECTS OF METFORMIN ON MEMORY RETRIEVAL AND HIPPOCAMPALCA1 AREA INTACT NEURONS IN STREPTOZOTOCIN-INDUCED ALZHEIMERIC MALE RATS,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 40, no. 5 , pp. 39–47, 2019, [Online]. Available: https://sid.ir/paper/46528/en

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