EFFECT OF CURCUMIN ON HISTOMORPHOMETRY OF ENDOMETRIUM IN POLYCYSTIC OVARIANSYNDROME IN MICE

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SADOUGHI SEYED DAMOON

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:40 | Issue:3 Page(s): 64-70

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Title

EFFECT OF CURCUMIN ON HISTOMORPHOMETRY OF ENDOMETRIUM IN POLYCYSTIC OVARIANSYNDROME IN MICE

Author(s)

SADOUGHI SEYED DAMOON | Issue Writer Certificate

Keywords

CURCUMINQ1

ENDOMETRIUMQ3

POLYCYSTIC OVARIAN SYNDROMEQ2

Abstract

Background: Polycystic ovary syndrome (PCOS) is a syndrome with complex endocrine and metabolicdisorders and also associated with endometrial changes. According to antioxidant and anti-inflammatory effects ofCURCUMIN, the aim of this study was to evaluate the effect of CURCUMIN on histomorphometry of ENDOMETRIUM inpolycystic ovarian syndrome mice model. Methods: In this experimental study 28 mice were divided into 4 equal groups. Control, PCOS control andexperimental PCOS treated with CURCUMIN (100 and 200 mg/kg, ip). PCOS was induced by a single intramuscularinjection of estradiol valerate into PCOS control group and experimental PCOS group. CURCUMIN wasintraperitoneally injected into experimental PCOS groups for 16 days. Saline solution was injected to the animals ofcontrol and PCOS control groups. At the end of treatment, the endometrial biopsies were stained with Hematoxylin-Eosin and pathological changes were examined. Data was analyzed using one-way ANOVA and Post Hoc Tukeystatistical tests (P<0. 05). Results: Compare to the control group, number of glands and thickness of endometrial significant decrease andthickness of epithelial cells and thickness of the endometrial glands epithelial cells significantly increase in PCOScontrol group (p<0. 05). Dose dependent injection of CURCUMIN was significantly improved histological parameterscompare to the PCOS control group (P<0. 05). Conclusion: Dose dependent administration of CURCUMIN improves the endometrial histological damages ofPCOS mice model.

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APA: Copy

SADOUGHI, SEYED DAMOON. (2018). EFFECT OF CURCUMIN ON HISTOMORPHOMETRY OF ENDOMETRIUM IN POLYCYSTIC OVARIANSYNDROME IN MICE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 40(3 ), 64-70. SID. https://sid.ir/paper/46770/en

Vancouver: Copy

SADOUGHI SEYED DAMOON. EFFECT OF CURCUMIN ON HISTOMORPHOMETRY OF ENDOMETRIUM IN POLYCYSTIC OVARIANSYNDROME IN MICE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;40(3 ):64-70. Available from: https://sid.ir/paper/46770/en

IEEE: Copy

SEYED DAMOON SADOUGHI, “EFFECT OF CURCUMIN ON HISTOMORPHOMETRY OF ENDOMETRIUM IN POLYCYSTIC OVARIANSYNDROME IN MICE,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 40, no. 3 , pp. 64–70, 2018, [Online]. Available: https://sid.ir/paper/46770/en

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