EFFECT OF N-ACETYLCYSTEINE TO PREVENT SODIUM-SELENITE INDUCED EXPERIMENTAL CATARACT

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JAVADZADEH A.R.; GHORBANI HAGHJOU A.; RASHTCHIZADEH N.; YOUSEFI ZANIAR; MESGARI M.

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:30 | Issue:3 Page(s): 31-35

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Title

EFFECT OF N-ACETYLCYSTEINE TO PREVENT SODIUM-SELENITE INDUCED EXPERIMENTAL CATARACT

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Keywords

EXPERIMENTAL CATARACTQ3

SODIUM SELENITEQ2

N-ACETYLCYSTEINEQ2

Abstract

Background and Objectives: Cataract is the most common cause of blindness in the world. Effect of some antioxidant on prevention of cataract progression was investigated. We investigate whether N-ACETYLCYSTEINE (NAC) prevents sodium-selenite induced cataract in Wistar rat eyes.Materials and Methods: Forty Wistar rats were randomized into 4 groups. In each group were 10 rats. In group I (control) subcutaneous and intraperitoneal 0.3 ml saline normal were injected on postpartum day 10. In group 2, SODIUM SELENITE (20 nmol/g body weight) subcutaneously and 0.3 ml saline normal intraperitonealy were injected on postpartum day 10.In group 3, SODIUM SELENITE (20 nmol/gbw) subcutaneously and N-ACETYLCYSTEINE (100 mg/kgbw) intraperitonealy were injected postpartum day 10. Intraperitoneal N-ACETYLCYSTEINE and subcutaneous saline normal were injected in group 4. The development of cataract was assessed weekly, and its density was graded by biomicroscopy and photography. Removed rat lenses were analyzed for glutathione (GSH), malondialdehyde (M.D.A, marker of lipid per oxidation), Superoxide dismutase (SOD) and glutathione peroxidase (GPX).Results: In group 3, all ofrats lenses were clear; however the Mean cataract stage in group 2 (sodium selenite) was 2.8±03 (p<0.05).The mean GSH, SOD and GPX level in group 2 was significantly lower than in groups 1, 3 and 4 (p<0.05),however the mean M.D.A level in group 2 was significantly higher than in groups 1, 3 and 4 (p<0.05).Conclusions: N-ACETYLCYSTEINE effectively suppressed cataract formation. The protective effect was supported by lower GSH, SOD and GPX; and higher M.D.A levels in group 2 than in group 3, suggesting the antioxidant efficacy of this agent.

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APA: Copy

JAVADZADEH, A.R., GHORBANI HAGHJOU, A., RASHTCHIZADEH, N., YOUSEFI, ZANIAR, & MESGARI, M.. (2008). EFFECT OF N-ACETYLCYSTEINE TO PREVENT SODIUM-SELENITE INDUCED EXPERIMENTAL CATARACT. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 30(3), 31-35. SID. https://sid.ir/paper/47301/en

Vancouver: Copy

JAVADZADEH A.R., GHORBANI HAGHJOU A., RASHTCHIZADEH N., YOUSEFI ZANIAR, MESGARI M.. EFFECT OF N-ACETYLCYSTEINE TO PREVENT SODIUM-SELENITE INDUCED EXPERIMENTAL CATARACT. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;30(3):31-35. Available from: https://sid.ir/paper/47301/en

IEEE: Copy

A.R. JAVADZADEH, A. GHORBANI HAGHJOU, N. RASHTCHIZADEH, ZANIAR YOUSEFI, and M. MESGARI, “EFFECT OF N-ACETYLCYSTEINE TO PREVENT SODIUM-SELENITE INDUCED EXPERIMENTAL CATARACT,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 3, pp. 31–35, 2008, [Online]. Available: https://sid.ir/paper/47301/en

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