EFFECT OF A HIGH-CHOLESTEROL DIET ON ANTIOXIDATIVE/PROOXIDATIVE BALANCE IN RABBITS

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DARBIN AKBAR; PEZESHKIYAN MASOOD; AFRASIYABI ABBAS; DOLATKHAH HOMAYUN; VATANKHAH AMIR MANSOUR; JAVADI LEYLA; RASHIDI MOHAMMAD REZA; NOURI MOHAMMAD

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2011 | Volume:33 | Issue:2 Page(s): 37-42

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Title

EFFECT OF A HIGH-CHOLESTEROL DIET ON ANTIOXIDATIVE/PROOXIDATIVE BALANCE IN RABBITS

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Keywords

CHOLESTEROLQ3

PARAOXONASE 1Q2

MALONDIALDEHYDEQ2

SUPEROXIDE DISMUTASEQ2

GLUTATHIONE PEROXIDASEQ2

Abstract

Background and Objectives: HyperCHOLESTEROLemia can increase oxidative stress through elevation of reactive oxygen species (ROS) production. The aim of the present study was to investigate the antioxidative/prooxidative balance in rabbits receiving high-CHOLESTEROL diet for two months.Materials and Methods: Sixteen rabbits were randomly divided into two groups: the control group which received 100 g normal chow diet daily; and the treatment group with the same diet plus 2% of CHOLESTEROL. The blood sample was obtained at first, days 20, 40, and 60 of the experiment. Plasma was separated and kept at -76oC until use. The lipid profile was determined using enzymatic method. SUPEROXIDE DISMUTASE and GLUTATHIONE PEROXIDASE activities were measured spectroscopically. MALONDIALDEHYDE (MDA) level and PARAOXONASE 1 (PON1) activity was determined by means of thiobarbituric acid and chemical methods, respectively.Results: At the end of intervention period, there was a significant increase in the plasma CHOLESTEROL (P=0.02), triglyceride (P<0.001), and LDL-C (P=0.041) concentrations; while level of HDL-C decreased significantly (P=0.036). The PON1 activity showed a decreased trend during the first two months reaching to 2.5 from 3.23 mmol/min/ml at the end of the experiment (P=0.001). However, there was about two-fold increase in the MDA level (from 6.77±0.91 to 14.50±3.00 nmol/ml, P=0.003). The SUPEROXIDE DISMUTASE and GLUTATHIONE PEROXIDASE activities were increased significantly (P=0.001 and P<0.001, respectively).Conclusion: An athrogenic diet can affect the lipid and lipoprotein profiles through changing the metabolic process. Meanwhile, this diet is also able to increase oxidative stress by disturbing antioxidative/prooxidative balance which, in turn, may lead to atherosclerosis development and progression.

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APA: Copy

DARBIN, AKBAR, PEZESHKIYAN, MASOOD, AFRASIYABI, ABBAS, DOLATKHAH, HOMAYUN, VATANKHAH, AMIR MANSOUR, JAVADI, LEYLA, RASHIDI, MOHAMMAD REZA, & NOURI, MOHAMMAD. (2011). EFFECT OF A HIGH-CHOLESTEROL DIET ON ANTIOXIDATIVE/PROOXIDATIVE BALANCE IN RABBITS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 33(2), 37-42. SID. https://sid.ir/paper/47409/en

Vancouver: Copy

DARBIN AKBAR, PEZESHKIYAN MASOOD, AFRASIYABI ABBAS, DOLATKHAH HOMAYUN, VATANKHAH AMIR MANSOUR, JAVADI LEYLA, RASHIDI MOHAMMAD REZA, NOURI MOHAMMAD. EFFECT OF A HIGH-CHOLESTEROL DIET ON ANTIOXIDATIVE/PROOXIDATIVE BALANCE IN RABBITS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;33(2):37-42. Available from: https://sid.ir/paper/47409/en

IEEE: Copy

AKBAR DARBIN, MASOOD PEZESHKIYAN, ABBAS AFRASIYABI, HOMAYUN DOLATKHAH, AMIR MANSOUR VATANKHAH, LEYLA JAVADI, MOHAMMAD REZA RASHIDI, and MOHAMMAD NOURI, “EFFECT OF A HIGH-CHOLESTEROL DIET ON ANTIOXIDATIVE/PROOXIDATIVE BALANCE IN RABBITS,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 33, no. 2, pp. 37–42, 2011, [Online]. Available: https://sid.ir/paper/47409/en

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