A STUDY OF CHROMOSOMAL ABNORMALITIES IN 50 PEDIATRIC PATIENTS REFERRED TO TABRIZ CHILDREN HOSPITAL

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HOSSEINPOUR FEYZI M.A.; HOSSEINPOUR FEYZI A.A.; SHOJAEI M.; AZARFAM P.

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2001 | Volume:- | Issue:50 Page(s): 35-40

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Title

A STUDY OF CHROMOSOMAL ABNORMALITIES IN 50 PEDIATRIC PATIENTS REFERRED TO TABRIZ CHILDREN HOSPITAL

Author(s)

HOSSEINPOUR FEYZI M.A. | HOSSEINPOUR FEYZI A.A. | SHOJAEI M. | AZARFAM P. | Issue Writer Certificate

Keywords

CHROMOSOMAL ABNORMALITIESQ4

LEUKEMIAQ3

BLOOD GROUPSQ4

Abstract

Background and Objectives: Cytogenetic abnormalities detected in pediatric LEUKEMIA has a significant role in relating disease’s pathophysiologic characteristics. The purpose of this study was to define chromosomal aberrations associated with LEUKEMIA in children.Materials and Methods: Bone marrow and peripheral blood samples were obtained from 50 children (33 males and 17 females) aged under 12 years with mean age of 6 years referred to Department of Hematology, Tabriz Children Hospital, Tabriz, from September 1997 to August 1998. Samples were analyzed by standard cytogenetic techniques to determine the karyotype.Results: GTG banding chromosomes were described according to ISCN classification. Acute LEUKEMIA (ALL) was the most common neoplasia of childhood(14 males and 8 females). Also, the majority patients in the study belonged to blood group A+(26%) (9 males and 4 females ). Chromosomal analysis of LEUKEMIA cells revealed the most significant chromosomal changes particularly aberrations such as translocation and acentric chromosomes (50%). The rate of chromosome aberrations in patients with LEUKEMIA showed significant difference compared with the control group (p<0.05).Conclusion: CHROMOSOMAL ABNORMALITIES detected in pediatric population is significant as an important prognostic factor in LEUKEMIA. The frequency and type of cytogenetic abnormalities was found comparable to those reported earlier in literature.

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APA: Copy

HOSSEINPOUR FEYZI, M.A., HOSSEINPOUR FEYZI, A.A., SHOJAEI, M., & AZARFAM, P.. (2001). A STUDY OF CHROMOSOMAL ABNORMALITIES IN 50 PEDIATRIC PATIENTS REFERRED TO TABRIZ CHILDREN HOSPITAL. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, -(50), 35-40. SID. https://sid.ir/paper/47524/en

Vancouver: Copy

HOSSEINPOUR FEYZI M.A., HOSSEINPOUR FEYZI A.A., SHOJAEI M., AZARFAM P.. A STUDY OF CHROMOSOMAL ABNORMALITIES IN 50 PEDIATRIC PATIENTS REFERRED TO TABRIZ CHILDREN HOSPITAL. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;-(50):35-40. Available from: https://sid.ir/paper/47524/en

IEEE: Copy

M.A. HOSSEINPOUR FEYZI, A.A. HOSSEINPOUR FEYZI, M. SHOJAEI, and P. AZARFAM, “A STUDY OF CHROMOSOMAL ABNORMALITIES IN 50 PEDIATRIC PATIENTS REFERRED TO TABRIZ CHILDREN HOSPITAL,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. -, no. 50, pp. 35–40, 2001, [Online]. Available: https://sid.ir/paper/47524/en

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