THE EVALUATION OF TOTAL ANTIOXIDANT CAPACITY AND RELATED MARKERS IN PATIENTS WITH CHRONIC PERITONEAL DIALYSIS

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EFTEKHAR E.; AHMADPOUR PEDRAM; RESHADATJOU M.; NOUROUZZADEH J.; MAKHDOUMI K.; GHAFARI ALI; SERVAT H.

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Journal: Journal of Kerman University of Medical Sciences Year:2008 | Volume:15 | Issue:1 Page(s): 29-36

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Title

THE EVALUATION OF TOTAL ANTIOXIDANT CAPACITY AND RELATED MARKERS IN PATIENTS WITH CHRONIC PERITONEAL DIALYSIS

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Keywords

PERITONEAL DIALYSISQ2

OXIDATIVE STRESSQ2

GLUTATHIONEQ3

GLUTATHIONE PEROXIDASEQ3

GLUTATHIONE REDUCTASEQ3

TOTAL ANTIOXIDANT CAPACITYQ3

Abstract

Introduction: OXIDATIVE STRESS due to overproduction of reactive oxygen species and impairment in antioxidant defense mechanisms have been suggested as possible factors contributing to the pathogenesis of atherosclerosis in patients with end- stage renal disease. The aim of this study was to evaluate antioxidant markers of OXIDATIVE STRESS including GLUTATHIONE and GLUTATHIONE related enzymes [i.e. GLUTATHIONE peroxidase (GPx) and GLUTATHIONE reductase (GR)] as well as TOTAL ANTIOXIDANT CAPACITY in PERITONEAL DIALYSIS (PD) patients.Methods: Twelve PD patients and 17 healthy controls (age range: 25-60 and 22-53 years respectively) were selected. Erythrocyte GLUTATHIONE levels and plasma activities of GPx, GR and TOTAL ANTIOXIDANT CAPACITY were determined spectrophtometrically.Results: GLUTATHIONE levels and GPx activity were significantly lower in the patients group than in controls (1.17± 0.28 vs. 1.42±0.25 mmol/ml and 57.1±21.8 vs. 142.5±31.7 U/L; p<0.05, respectively). Higher levels of GR activity and TOTAL ANTIOXIDANT CAPACITY were noted in patient group (57.5±16.4 U/L and 0.60±0.09 mmol/ml; respectively) in comparison to control group (32±9.4 U/L and 0.47±0.11 mmo/ml; p<0.05, respectively). Conclusion: Decreased GLUTATHIONE levels and alteration in the activities of its related enzymes imply increased OXIDATIVE STRESS and disturbances of antioxidant defense systems in PERITONEAL DIALYSIS patients. This condition may contribute to the development of accelerated cardiovascular disease and its morbidity and mortality in these patients.

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APA: Copy

EFTEKHAR, E., AHMADPOUR, PEDRAM, RESHADATJOU, M., NOUROUZZADEH, J., MAKHDOUMI, K., GHAFARI, ALI, & SERVAT, H.. (2008). THE EVALUATION OF TOTAL ANTIOXIDANT CAPACITY AND RELATED MARKERS IN PATIENTS WITH CHRONIC PERITONEAL DIALYSIS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 15(1), 29-36. SID. https://sid.ir/paper/478/en

Vancouver: Copy

EFTEKHAR E., AHMADPOUR PEDRAM, RESHADATJOU M., NOUROUZZADEH J., MAKHDOUMI K., GHAFARI ALI, SERVAT H.. THE EVALUATION OF TOTAL ANTIOXIDANT CAPACITY AND RELATED MARKERS IN PATIENTS WITH CHRONIC PERITONEAL DIALYSIS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;15(1):29-36. Available from: https://sid.ir/paper/478/en

IEEE: Copy

E. EFTEKHAR, PEDRAM AHMADPOUR, M. RESHADATJOU, J. NOUROUZZADEH, K. MAKHDOUMI, ALI GHAFARI, and H. SERVAT, “THE EVALUATION OF TOTAL ANTIOXIDANT CAPACITY AND RELATED MARKERS IN PATIENTS WITH CHRONIC PERITONEAL DIALYSIS,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 1, pp. 29–36, 2008, [Online]. Available: https://sid.ir/paper/478/en

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