EFFECTS OF CENTRAL AND PERIPHERAL DEPLETION OF SEROTONERGIC SYSTEM ON CARRAGEENAN INDUCED PAW OEDEMA

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MALEKI N.; MOHAJEL NAEBI ALI REZA; GARJANI A.; FAKHRJOU A.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:1 Page(s): 75-84

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Title

EFFECTS OF CENTRAL AND PERIPHERAL DEPLETION OF SEROTONERGIC SYSTEM ON CARRAGEENAN INDUCED PAW OEDEMA

Author(s)

MALEKI N. | MOHAJEL NAEBI ALI REZA | GARJANI A. | FAKHRJOU A. | Issue Writer Certificate

Keywords

SEROTONINQ3

INFLAMMATIONQ3

CARRAGEENANQ2

PARACHLOROPHENYLALANINEQ2

MYELOPEROXIDASEQ2

CENTRAL NERROW SYSTEMQ2

RATSQ2

Abstract

The role of serotonergic system was investigated on peripheral INFLAMMATION induced by intraplantary injection of CARRAGEENAN. Para-chlorophenylalanine (pCPA) was administered intracerebroventriculary (50, 100 μg/rat) or intraperitoneally (150 mg/kg, 3 days) and INFLAMMATION was induced by injection of CARRAGEENAN, 2 hours and 1 day later, respectively. Paw oedema was decreased significantly in pCPA-treated (100 μg/rat, i.c.v.) RATS compared to control groups. Injection of exogenous SEROTONIN (i.c.v.) by dose of 0.70 nmol/10μl/rat, but not the dose of 0.35 nmol/10μl/rat, 15 min after induction of INFLAMMATION completely reversed the anti-inflammatory effects of pCPA. MYELOPEROXIDASE activity in inflamed paws were reduced significantly in groups who received (either i.c.v. or i.p.) pCPA compared to controls. Exogenous SEROTONIN (0.70 nmol/10μl/rat) reduced inflammatory response when injected (i.c.v.) 30 min before or 30 min after the induction of INFLAMMATION. Injection of SEROTONIN at the time of induction of INFLAMMATION had no inflammatory/antiinflammatory effect. These results suggest that SEROTONIN, as a neurotransmitter in central nervous system, may be involved in modulating peripheral INFLAMMATION.

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APA: Copy

MALEKI, N., MOHAJEL NAEBI, ALI REZA, GARJANI, A., & FAKHRJOU, A.. (2005). EFFECTS OF CENTRAL AND PERIPHERAL DEPLETION OF SEROTONERGIC SYSTEM ON CARRAGEENAN INDUCED PAW OEDEMA. PHARMACEUTICAL SCIENCES, -(1), 75-84. SID. https://sid.ir/paper/48429/en

Vancouver: Copy

MALEKI N., MOHAJEL NAEBI ALI REZA, GARJANI A., FAKHRJOU A.. EFFECTS OF CENTRAL AND PERIPHERAL DEPLETION OF SEROTONERGIC SYSTEM ON CARRAGEENAN INDUCED PAW OEDEMA. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(1):75-84. Available from: https://sid.ir/paper/48429/en

IEEE: Copy

N. MALEKI, ALI REZA MOHAJEL NAEBI, A. GARJANI, and A. FAKHRJOU, “EFFECTS OF CENTRAL AND PERIPHERAL DEPLETION OF SEROTONERGIC SYSTEM ON CARRAGEENAN INDUCED PAW OEDEMA,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 75–84, 2005, [Online]. Available: https://sid.ir/paper/48429/en

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