Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Issue Information

مرکز اطلاعات علمی SID1
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Title: 
Author(s): 

Issue Info: 
  • Year: 

    0
  • Volume: 

    11
  • Issue: 

    1
  • Pages: 

    -
Measures: 
  • Citations: 

    0
  • Views: 

    6191
  • Downloads: 

    0
Keywords: 
Abstract: 

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 6191

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 0 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 0 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 0
Issue Info: 
  • Year: 

    2005
  • Volume: 

    -
  • Issue: 

    1
  • Pages: 

    1-8
Measures: 
  • Citations: 

    0
  • Views: 

    2171
  • Downloads: 

    557
Abstract: 

The objective of this study was to investigate the serum vitamin E status and value of vitamin E / TC and vitamin E / LDL-C in women who use low-dose oral contraceptives (OCs) containing 0.15 mg levonorgestrol and 0.03 mg ethinyl estradiol and also in postmenopausal women who take hormone replacement therapy (HRT). One hundred – thirty nine healthy non pregnant–non lactating women with a mean age of 32 years old (70 were OCs users and 69 were non-OCs users) and sixty healthy postmenopausal women, with a mean age of 51 years old (30 were under HRT and 30 were untreated) were studied using biochemical procedures (measurement of serum vitamin E and lipids levels), anthropometric measurements(weight and height)and interview with the subjects. No significant difference was found between either OCs and non-OCs users or HRT and non-HRT groups in terms of mean body mass index (BMI), and dietary intakes of vitamin E, total fat and total fiber. There were no significant differences between serum vitamin E levels and the mean value of vitamin E/TC in either OCs-users and non-OCs users or HRT and non-HRT groups. The mean value of vitamin E/LDL-C in HRT group was significantly higher than that of non-HRT group (7.13±3.48 vs 5.32±2.10, p<0.01). There was no significant difference between mean value of vitamin E/LDL-C in OCs and non-OCs groups. As a conclusion, using low-dose OCs has not resulted in altered vitamin E metabolism in OCs-Users compared to non-OCs Users. However, in postmenopausal women, taking HRT have had positive effect on serum vitamin E/LDL-C ratio, which is suitable indicator of vitamin E status.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 2171

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 557 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 0 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 0
Issue Info: 
  • Year: 

    2005
  • Volume: 

    -
  • Issue: 

    1
  • Pages: 

    9-14
Measures: 
  • Citations: 

    0
  • Views: 

    6257
  • Downloads: 

    1376
Abstract: 

The purpose of this study was to evaluate the validity routine methods of heparin administration and neutralizing its effects by protamine in patients who underwent the open heart surgery using Cardiopulmonary Bypass (CPB) technique, in the comparison of administered amount of this agent through the classical methods, by controlling the ACT (Activated clotting time). In the classical way, the maintenance of heparin and protamine doses are determined and injected according to the ACT-heparin curve. The subjects of this study were 100 patients who underwent surgery of coronary vessel graft (68%), valve replacement (28%) and repairing congenital defects (4%) and the CPB was conducted on them. After conventionally taking the ACT as control, 3mg/kg heparin was injected and per hour 50mg maintained doses were administered. The Act specimens were collected after the injection of heparin and also at the end of CPB before protamine injection. The fourth sample of Act was collected after neutralizing the heparin effects by 4.5 mg/kg of protamine. The results of 4 ACT samples were analyzed with expected and standard values (Control Act = 120 sec and Act during pumping>400 sec) by One Sample t-test. There was no significant difference between the average control Act of the patients before heparin injection (128.8 sec) and the normal value of 120 sec (P=0.2), while there was significant difference between average Act after heparin injection (572 sec) and Act value before protamine injection (599 sec) and the expected value of 400 sec during CPB (P=0.0001 and P=0.0001, respectively). There was also no significant difference between average Act after protamine injection (124.9 sec) and the normal value of 120 sec. It is revealed in this paper that when the Act procedure is not available, the routine method of 50mg heparin injection per hour and neutralizing the heparin effects by 1.5mg doses of protamine per each mg of injected heparin, possesses the necessary validity and it may be practical for the patients.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 6257

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 1376 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 0 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 0
Author(s): 

GHOUTASLOU REZA

Issue Info: 
  • Year: 

    2005
  • Volume: 

    -
  • Issue: 

    1
  • Pages: 

    15-20
Measures: 
  • Citations: 

    0
  • Views: 

    772
  • Downloads: 

    598
Abstract: 

Cefepime is a semi-synthetic, broad spectrum, cephalosporin antibiotic for parenteral administration. Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. It has a broad spectrum of In vitro activity against wide range of gram positive and gram-negative bacteria. In a prospective study 100 of bacterial species were studied by a susceptibility test by disk diffusion (Kirby–Bauer) in Tabriz Pediatric Medical Center. This study compares inhibitory effect of cefepime with that of Penicillin, Chloramphenicol, Ampicillin, Cotrimoxazol, Gentamycin, Cefotaxime, Vancomycin, Ciprofloxacin, Ceftriaxone, Amikacin and Erythromycin on Klebsiella pneumoniae, Staphylococci coagulase negative, Pseudomonas aeruginosa, Staphylococcus aureus, Serratia marcescens, Salmonella Sp, Enterobacter cloacae, Proteus mirabilis, Acinetobacter Sp and Streptococcus Sp. During 6 month in 100 bacterial strains (clinical isolated), the resistance to cefepime on Pseudomonas aeroginosa (100%), Klebsiella pneumoniae (46%), Staphylococcus aureus (40%), Staphylococci coagulase negative (40%), Enterobacter cloacae (40%), Acintobacter sp (30%), Proteus mirabilis (20%), E.coli (6%), Streptococcus non group A (0%) Seratia marcescens (0%), Salmonella non typhi (0%) were respectively. The In vitro inhibitory effect of cefepime on Pseudomonas aeroginosa was found to be less than other bacteria, Whereas Streptococcus SP, Seratia marcescens, Salmonella and E.coli was more sensitive to cefepime. The inhibitory effect of cefepime on bacterial isolations and it’s comparison with other antibiotics demonstrate a broad spectrum of activity of cefepime. And the resistant bacterial strains were developed against this antibiotic in this area.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 772

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 598 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 0 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 1
Issue Info: 
  • Year: 

    2005
  • Volume: 

    -
  • Issue: 

    1
  • Pages: 

    21-30
Measures: 
  • Citations: 

    0
  • Views: 

    2579
  • Downloads: 

    796
Abstract: 

Phosphorous binders such as calcium carbonate (CC) and aluminum hydroxide have been used in Chronic Renal Failure (CRF) patients to decrease hyperphosphatemia. The aim of this study was to prepare calcium acetate (CA) tablets and evaluate their effects in CRF patients. CA tablets were prepared by wet granulation method and their physicochemical properties such as weight variation, hardness, friability, disintegration time and dissolution rate were studied. Calcium was determined by atomic absorption method. The in vitro phosphorus binding capacity of CA was evaluated and compared with CC tablets marketed in Iran. The stability of prepared tablets was studied as well. Clinical usefulness of CA as phosphorus binder was assessed in 24 adult patients. Mean weight, hardness and disintegration time of CA tablets were 1161.5 mg, 49.5 N and 34.5 min, respectively. Percent of the drug released after 30 and 60 minutes were 76.2% and 97.6%, respectively. The tablets released 50% of their content up to 18.4 min. Percent of phosphorus insolublized as calcium phosphate by CC and CA were 30.7% and 16.2% respectively. CA tablets disintegration time in acidic, neutral and basic media were 39.5, 34.4 and 42.2 min. Physicochemical properties of tablets during the stability test condition were acceptable based on FDA standards. CA decreased serum phosphorus concentration more effectively than CC.Our data confirm that a given dose of calcium administrated orally as CA, binds more phosphorus in the intestine than the same dose of CC. This may be due to the better solubility of CA.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 2579

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 796 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 0 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 0
Issue Info: 
  • Year: 

    2005
  • Volume: 

    -
  • Issue: 

    1
  • Pages: 

    31-38
Measures: 
  • Citations: 

    0
  • Views: 

    629
  • Downloads: 

    470
Abstract: 

Capacity factors of phenobarbital, phenytoin and carbamazepine in mobile phases containing water and the organic modifiers: methanol, acetonitrile, acetone and tetrahydrofuran were determined and the obtained results fitted to the proposed model: Ink'=J1ø1 + J2ø2 + ø1ø2∑pi=0 Bi (ø1-ø2)iWhere k’ is the capacity factor of the analyte, φ1 and φ2 are the volume fractions of solvents 1 and 2, J1, J2 and Bi are the model constants. Average percentage deviation (APD) was computed as an accuracy criterion for the proposed model, the linear model of Schoenmarkers and the cubic equation of Jandera and the obtained mean and standard deviation of APDs were 14.6±10.7, 42.3±11.2 and 32.7±17.8 %, respectively. The accuracy of the models was also checked using collected data from the literature and the calculated values were 1.64±0.85, 22.11 ± 2.48 and 4.87±1.98 %, respectively. The results showed that the proposed model provided more accurate computations in comparison with the previously published models and the mean differences were statistically significant.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 629

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 470 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 0 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 0
Author(s): 

DAVARAN S. | HANAEI J. | MOLAEI J.

Issue Info: 
  • Year: 

    2005
  • Volume: 

    -
  • Issue: 

    1
  • Pages: 

    39-46
Measures: 
  • Citations: 

    0
  • Views: 

    985
  • Downloads: 

    399
Abstract: 

Three kinds of PEGylated derivatives of ibuprofen have been prepared and their hydrolytic behavior have been studied in aqueous buffered solutions (pH 1, 7.8 , 4).The PEGylated derivatives of ibuprofen comprised of the low molecular weight derivatives of the drug and poly ethylene glycol (PEG) units connected by labile ester, amide, or thioester bonds. Ibuprofen converted to its hydroxyethyl ester (HEE), hydroxyethyl amide (HEA), or ydroxyethyl thioester (HETA) derivatives and coupled to monomethoxy polyethylene glycol mono succinate (PEG- COOH). All three PEGylated derivatives of ibuprofen released the drug gradually as a function of time and pH. In HEE- PEG the amount of released drug was lower, while the difference between acidic and alkali buffered solutions was not as large. HETE- PEG in acidic medium ibuprofen released to a much smaller extent than in basic medium. HEA- PEG had a notable stability in buffered solutions and showed a small acceleration of hydrolysis rate in human plasma due to the catalysis by esterase's present in the plasma.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 985

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 399 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 0 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 0
Author(s): 

NAJAFI M. | GARJANI A.

Issue Info: 
  • Year: 

    2005
  • Volume: 

    -
  • Issue: 

    1
  • Pages: 

    47-52
Measures: 
  • Citations: 

    1
  • Views: 

    1149
  • Downloads: 

    498
Abstract: 

Carnitine is a vital biologic substance for transporting fatty acids into myocytes and facilitates fatty acids β-oxidation for energy production. There are some conflicting findings about its cardioprotective effects such as decreasing the infarct size during ischemia / reperfusion. In this study, the effects of L-Carnitine on infarct size in the ischemic isolated rat hearts were investigated. Male Sprague-Dawley rats (270-330g) were divided into 5 groups randomly and they were anesthetized by sodium pentobarbital (50-60 mg/kg-ip).Heart was removed and quickly mounted on a Langendorff apparatus and perfused by a modified Krebs -Henseleit solution under constant pressure at 37 C º. In control group (n=6), the hearts were perfused only by normal Krebs -Henseleit solution at stabilization, 30 min regional ischemia and120 min reperfusion, while in the test groups (1-4 groups , n=6 in each group), during ischemia / reperfusion , the hearts were perfused with 0.5,2.5,3.75 and 5mM of L-Carnitine - enriched Krebs -Henseleit solution , respectively. At the end of reperfusion, 1% Evans Blue solution was infused to stain the non-ischemic area. Then the heart was cut into slices and incubated by 1% Triphenyltetrazolium chloride (TTZ) solution and fixed by formalin. The area of infracted tissue and area at risk were determined by computerized planimetry. In control group, the infarct size was 46.29 ±3.46%, while in the test groups, the addition of L-Carnitine (0.5, 2.5, 3.75 and 5mM) into the Krebs solution during ischemia and reperfusion, reduced infarct size to 27 ± 2.85, 25.53 ± 5.40, 19.53 ± 4.88 and15.68 ± 2.78 %, respectively (p<0.001).The effect was dose-dependent at the doses of 0.5 – 5mM.There was no significant difference between and within test groups using ANOVA oneway test. Considering these results, we conclude that L-carnitine has a protective effect against cardiac ischemic reperfusion injuries and reduces the infarct size.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 1149

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 498 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 1 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 0
Issue Info: 
  • Year: 

    2005
  • Volume: 

    -
  • Issue: 

    1
  • Pages: 

    53-66
Measures: 
  • Citations: 

    0
  • Views: 

    919
  • Downloads: 

    569
Abstract: 

Drug targeting to the brain is one of the most challenging areas of biopharmaceutical investigations due to the presence of the blood-brain barrier (BBB). Up until now, no cell culture models were shown to represent a well-characterized in vitro BBB model to be utilized for drug delivery and targeting to the brain. Cell lines derived from brain endothelium lack the ability to generate a restrictive barrier function despite possessing some characteristics of BBB such as carrier mediated transporters. Among cell lines used as in vitro cell-based BBB models, we aimed to evaluate the most studied cell line (ECV304 cell line) for its bioelectrical properties and permeability characteristics upon treatments with astrocytic factors (using rat glioma C6 cells) in the absence or presence of various modulators including extra-cellular matrix and some other tight junction modulators (i.e, cAMP elevators, retinoic acid, dexamethasone, and γ-linolenic acid). Significant (p<0.05) increase in trans-endothelial electrical resistance (TEER) values was only observed for ECV304 cells cocultured with astrocytes and treated with cAMP elevators (110 Ω.cm2), however such TEER is not comparable to that of in vivo (1500-2000 Ω.cm2). ECV304 cells cocultured with astrocytes and treated with cAMP elevators displayed the highest discrimination for permeability coefficients of trans-cellular marker propranolol (25×10-6 cm/sec) and para-cellular marker sucrose (11.3×10-6 cm/sec). The permeability coefficient ratio of propranolol over sucrose was 2 which is much lower than that of primarily isolated porcine brain microvascular endothelial cells. ECV304 cells failed to generate restrictive para-cellular barrier, thus it is not suggested to be used as an in vitro BBB model for drug screening although its usefulness has been shown for carrier-mediated transport studies.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 919

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 569 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 0 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 0
Issue Info: 
  • Year: 

    2005
  • Volume: 

    -
  • Issue: 

    1
  • Pages: 

    67-74
Measures: 
  • Citations: 

    0
  • Views: 

    3293
  • Downloads: 

    731
Abstract: 

Sustained release formulations have many advantages over the conventional dosage forms. There are various techniques to control the release rate of drugs, among which, controlling drug s dissolution rate is most popular due to its success and low cost. Although there are numerous studies to produce sustained release formulations, little studies were carried out to use solid dispersion technique to produce sustained release formulations. Propranolol is a β adrenergic receptor blocker that has some adverse effects. These side effects could be reduced by reduction of usage frequency and producing steady pharmacological effects by preparing sustain release formulation. In this study we tried to use solid dispersion technique to slow down the release rate in water from its tablet formulation. Solid dispersion formulations were prepared using molten-solvent technique. The final obtained powder was compressed into tablets and their dissolution were investigated at pH 1.2 and 6.8. FT-IR was used to find any interaction between the drug and excipient. The results showed that solid dispersions produced harder tablets than that of physical mixtures formulations. The amount of eduragit had no significant effect on release rate. It was interesting to note that solid dispersions containing PEG 6000 and eudragit had slow release rate. This indicates that the presence of PEG 6000 to slow down the release of propranolol from eudragit solid dispersion matrices is necessary. It was found that type of Eudragit had not significant effect on the release rate of propranolol from solid dispersions. Ethylcelllose alone was not able to decrease the release rate. Although PEG 6000 is hydrophilic excipient, the reduced release rate in presence of PEG 6000 is due to the enhance effect of PEG 6000 on the hardness of tablets. FT-IR study showed no interaction between the drug and excipients.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 3293

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 731 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 0 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 0
Issue Info: 
  • Year: 

    2005
  • Volume: 

    -
  • Issue: 

    1
  • Pages: 

    75-84
Measures: 
  • Citations: 

    0
  • Views: 

    776
  • Downloads: 

    521
Abstract: 

The role of serotonergic system was investigated on peripheral inflammation induced by intraplantary injection of carrageenan. Para-chlorophenylalanine (pCPA) was administered intracerebroventriculary (50, 100 μg/rat) or intraperitoneally (150 mg/kg, 3 days) and inflammation was induced by injection of carrageenan, 2 hours and 1 day later, respectively. Paw oedema was decreased significantly in pCPA-treated (100 μg/rat, i.c.v.) rats compared to control groups. Injection of exogenous serotonin (i.c.v.) by dose of 0.70 nmol/10μl/rat, but not the dose of 0.35 nmol/10μl/rat, 15 min after induction of inflammation completely reversed the anti-inflammatory effects of pCPA. Myeloperoxidase activity in inflamed paws were reduced significantly in groups who received (either i.c.v. or i.p.) pCPA compared to controls. Exogenous serotonin (0.70 nmol/10μl/rat) reduced inflammatory response when injected (i.c.v.) 30 min before or 30 min after the induction of inflammation. Injection of serotonin at the time of induction of inflammation had no inflammatory/antiinflammatory effect. These results suggest that serotonin, as a neurotransmitter in central nervous system, may be involved in modulating peripheral inflammation.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 776

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 521 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 0 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 0
Issue Info: 
  • Year: 

    2005
  • Volume: 

    -
  • Issue: 

    1
  • Pages: 

    85-95
Measures: 
  • Citations: 

    1
  • Views: 

    2815
  • Downloads: 

    1048
Abstract: 

The purpose of the present study was to prepare diclofenac diethyl amine emulgel with better skin penetration compared to the marketed product in Iran. To achieve such a product, several formulations containing different kinds and amounts of gelling agents, have been prepared. By changing the type and amount of gelling agent, type and ratio of organic phase composition, and solvent amount the best formulation with better stability has been selected. The skin penetration study was carried out using skin penetration study apparatus equipped with Franz cells. The concentration of drug in the receptor phase of Franz cells was determined using UV spectrophotometer and HPLC. To evaluate the effect of type and concentration of skin penetration enhancer agents on the penetration of drug through rat skin, Transcutol, Myrj 52 and Cineol was used with different concentrations. After calculating flux and EF values and comparing the graph of cumulative amount of drug penetrated through the skin, the formulation which had 0.25% Myrj 52 as skin penetration enhancer was selected as the best formulation with higher skin penetration.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 2815

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesDownload 1048 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesCitation 1 مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic ResourcesRefrence 0