ANALGESIC EFFECT OF METHANOLIC EXTRACT OF ERICA ARBOREA IN MICE BY USING HOT PLATE TEST

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAJEL NAEBI ALI REZA; RAJABLI B.; NAZEMIEH H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: PHARMACEUTICAL SCIENCES Year:2008 | Volume:- | Issue:2 Page(s): 45-51

Download Full-Text

Persian Verion

View:

1,249

Download:

Cites:

Information Journal Paper

Title

ANALGESIC EFFECT OF METHANOLIC EXTRACT OF ERICA ARBOREA IN MICE BY USING HOT PLATE TEST

Author(s)

MOHAJEL NAEBI ALI REZA | RAJABLI B. | NAZEMIEH H. | Issue Writer Certificate

Keywords

ERICA ARBOREQ2

ANALGESIAQ2

HOT PLATE TESTQ2

Abstract

Objectives: ERICA ARBOREa L. (EA, Ericaceae) is a topical shrub or small tree predominantly found in all around the Mediterranean area such as Çanakkale, Turkey, which is used traditionally as a diuretic, urinary antiseptic, anorexiant and against constipation. However, its other pharmacological effects have not been yet elucidated clearly. The aim of this study was to investigate the analgesic effect of its hydroalcoholic-extract on HOT PLATE TEST, as a model of thermal acute pain. Methods: Study was carried out on male Swiss mice weighing 30-35 g. In order to study acute pain, HOT PLATE TEST with set point 50±1oC and cut off time 50 Sec was used. Methanolic extract of aerial parts was prepared by maceration method and then its analgesic effect was studied at the doses of 10, 20 and 30 mg/kg, i.p. In addition, the methanolic fractions of 20, 40, 60, 80 and 100% were prepared by solid phase extraction method, and then their analgesic effect was investigated at the dose of 5 mg/kg, i.p. The effect of methanolic extract and fractions were compared with the analgesic effect of morphine (10 mg/kg, i.p.) as a standard analgesic drug. Results: Results obtained from this study showed that methanolic extract of EA had analgesic effect (P<0.05) at the dose of 10 mg/kg, i.p. The analgesic effect of extract was less than (P<0.05) morphine (10 mg/kg, i.p.). Among the prepared-methanolic fractions, only the fraction 20% (10 mg/kg, i.p.) caused significant (P<0.05) ANALGESIA. Moreover, the methanolic extract (10 mg/kg, i.p.) has not any motor deficit effect in rotarod test. Conclusion: We conclude that total methanolic extract and faction 20% of EA have a good pain relief effect in HOT PLATE TEST. The analgesic effect of EA was also comparable to that of morphine, as a well known analgesic drug. In order to relate the analgesic effect of EA to particular phytochemicals, further investigations should be done.

Cites

ANALGESIC EFFECT OF THE METHANOL EXTRACT OF ERICA ARBOREA (L.) IN MICE USING FORMALIN TEST

References

No record.

Cite

APA: Copy

MOHAJEL NAEBI, ALI REZA, RAJABLI, B., & NAZEMIEH, H.. (2008). ANALGESIC EFFECT OF METHANOLIC EXTRACT OF ERICA ARBOREA IN MICE BY USING HOT PLATE TEST. PHARMACEUTICAL SCIENCES, -(2), 45-51. SID. https://sid.ir/paper/48461/en

Vancouver: Copy

MOHAJEL NAEBI ALI REZA, RAJABLI B., NAZEMIEH H.. ANALGESIC EFFECT OF METHANOLIC EXTRACT OF ERICA ARBOREA IN MICE BY USING HOT PLATE TEST. PHARMACEUTICAL SCIENCES[Internet]. 2008;-(2):45-51. Available from: https://sid.ir/paper/48461/en

IEEE: Copy

ALI REZA MOHAJEL NAEBI, B. RAJABLI, and H. NAZEMIEH, “ANALGESIC EFFECT OF METHANOLIC EXTRACT OF ERICA ARBOREA IN MICE BY USING HOT PLATE TEST,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 45–51, 2008, [Online]. Available: https://sid.ir/paper/48461/en

Related Journal Papers