EVALUATION OF BASE TYPE AND SURFACE- ACTIVE AGENTS IN RELEASE RATE OF NAPROXEN FROM SUPPOSITORIES

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FARID J.; AZARMI SH.; JAVADZADEH Y.; HARGOLI S.

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Journal: PHARMACEUTICAL SCIENCES Year:2001 | Volume:- | Issue:1 Page(s): 75-84

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Title

EVALUATION OF BASE TYPE AND SURFACE- ACTIVE AGENTS IN RELEASE RATE OF NAPROXEN FROM SUPPOSITORIES

Author(s)

FARID J. | AZARMI SH. | JAVADZADEH Y. | HARGOLI S. | Issue Writer Certificate

Keywords

NAPROXENQ2

NAPROXEN SUPPOSITORIES FORMULATIONQ3

NON-STROIDAL ANTI INFLAMMATORYQ3

DRUG RELEASEQ3

Abstract

NAPROXEN (NP) a potent non-steroidal anti inflammatory drug is used in most musculoskeletal disorders such as rheumatoid arthritis. Since NP can damage the mucous of gastrointestinal tract, suppository dosage form can be useful in circumventing this side effect. In this research NP suppositories were formulated using different oleogineous and water soluble bases. After performing different physicochemical controls, the dissolution studies were accomplished. The time for the release of total drug from suppositories were 180 and 200 minutes for oleoginous and water soluble bases respectively. To optimize the release rate of drug from suppositories, different surfactants, (nonionic, anionic and cationic), were included in bases in concentration of 0.5% and 1% w/w. the results showed that Tween 80 (0.5%w/w) in witepsol H.15 base and cetyl pyridinium chloride (0.5%w/w) in witepsol W35 caused the decrease in time for total release of drug respectively to 45 and 60 minutes, However, non of surfactants had pronounced effect on the release of drug from the water soluble bases.

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APA: Copy

FARID, J., AZARMI, SH., JAVADZADEH, Y., & HARGOLI, S.. (2001). EVALUATION OF BASE TYPE AND SURFACE- ACTIVE AGENTS IN RELEASE RATE OF NAPROXEN FROM SUPPOSITORIES. PHARMACEUTICAL SCIENCES, -(1), 75-84. SID. https://sid.ir/paper/48473/en

Vancouver: Copy

FARID J., AZARMI SH., JAVADZADEH Y., HARGOLI S.. EVALUATION OF BASE TYPE AND SURFACE- ACTIVE AGENTS IN RELEASE RATE OF NAPROXEN FROM SUPPOSITORIES. PHARMACEUTICAL SCIENCES[Internet]. 2001;-(1):75-84. Available from: https://sid.ir/paper/48473/en

IEEE: Copy

J. FARID, SH. AZARMI, Y. JAVADZADEH, and S. HARGOLI, “EVALUATION OF BASE TYPE AND SURFACE- ACTIVE AGENTS IN RELEASE RATE OF NAPROXEN FROM SUPPOSITORIES,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 75–84, 2001, [Online]. Available: https://sid.ir/paper/48473/en

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