ELECTROCARDIOGRAPHIC MANIFESTATIONS OF EXPERIMENTAL DIGOXIN TOXICITY IN DOGS

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MAHAM M.; HEMMATI M.

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Journal: PHARMACEUTICAL SCIENCES Year:2004 | Volume:- | Issue:2 Page(s): 1-10

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Information Journal Paper

Title

ELECTROCARDIOGRAPHIC MANIFESTATIONS OF EXPERIMENTAL DIGOXIN TOXICITY IN DOGS

Author(s)

MAHAM M. | HEMMATI M. | Issue Writer Certificate

Keywords

DIGOXINQ2

TOXICITYQ3

DOGQ3

CARDIAC DYSRHYTHMIAQ3

Abstract

The cardiac glycosides have been used in treatment of cardiac disease over two centuries. DIGOXIN is the most commonly prescribed cardiac glycoside due to its convenient pharmacokinetics, intravenous and oral preparations. Unfortunately the margin between therapeutic and toxic dose of DIGOXIN is very small and TOXICITY occurs frequently. In the present study TOXICITY of DIGOXIN was studied in DOGs using electrocardiography and clinical signs in monitoring the progress of intoxication. Thirteen healthy, mature, native DOGs weighing between 14 and 33 kg were used. The DOGs were randomly divided into three groups. DOGs in group one (n=5) were given DIGOXIN (oral + i.v.) and electrocardiographic manifestations of poisoning have been studied. Electrocardiography studies revealed bradycardia initially (while in some, sinus tachycardia was observed first), accompanied by T-wave changes and Premature ventricular beats, which progressed, to multifocal Premature ventricular beats, AV dissociation, ventricular tachycardia and ventricular fibrillation. DOGs in group two (n=3) were administrated hydrochloric acid (0.1 N) intravenously. In this group electrocardiographic disturbances have not been observed. DOGs in group three (n=5) were given DIGOXIN (as same as group one) and when CARDIAC DYSRHYTHMIAs were initiated, hydrochloric acid was administered (as same as group two). It is concluded that DIGOXIN TOXICITY in the DOG increases automaticity and delays conduction of the heart and hydrochloric acid h- not significant effects on DIGOXIN induced cardiac dyarhythmias.

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APA: Copy

MAHAM, M., & HEMMATI, M.. (2004). ELECTROCARDIOGRAPHIC MANIFESTATIONS OF EXPERIMENTAL DIGOXIN TOXICITY IN DOGS. PHARMACEUTICAL SCIENCES, -(2), 1-10. SID. https://sid.ir/paper/48483/en

Vancouver: Copy

MAHAM M., HEMMATI M.. ELECTROCARDIOGRAPHIC MANIFESTATIONS OF EXPERIMENTAL DIGOXIN TOXICITY IN DOGS. PHARMACEUTICAL SCIENCES[Internet]. 2004;-(2):1-10. Available from: https://sid.ir/paper/48483/en

IEEE: Copy

M. MAHAM, and M. HEMMATI, “ELECTROCARDIOGRAPHIC MANIFESTATIONS OF EXPERIMENTAL DIGOXIN TOXICITY IN DOGS,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 1–10, 2004, [Online]. Available: https://sid.ir/paper/48483/en

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