EVALUATION OF THE ROLE OF S-HT1A RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT

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CHARKHPOUR M.; MOHAJEL NAEBI ALI REZA

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Title

EVALUATION OF THE ROLE OF S-HT1A RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT

Author(s)

CHARKHPOUR M. | MOHAJEL NAEBI ALI REZA | Issue Writer Certificate

Keywords

5-HT1A RECEPTORSQ2

DORSAL RAPHE NUCLEUSQ2

MEDIAN RAPHE NUCLEUSQ2

MORPHINEQ2

WITHDRAWALQ2

Abstract

OBJECTIVES: The present study was performed to investigate the role of 5-HT 1A Receptors in dorasal and median raphe nuclei on the WITHDRAWAL syndrome of MORPHINE and acceleration the restraint of opioides. METHODS: Experiments were performed on adult male wistar weighing between 225 and 275 g. The control group (n=8)bad 9 days s.c. injections of MORPHINE (5, 10, 10, 15, 15, 20, 20. 25, 25mg/kg12h) and the last day, 60 minutes after first injection of MORPHINE 5mg/kg naloxone was injected (i.p.) and sips of WITHDRAWAL syndrome were recorded until 60 minutes. In the sham and test group following inductionanoesthesia, rats were secured in a stereotaxic frame with ear and incisor bars. Then a guide cannuls was implanted into the DRN and MRN in the separated groups (0=8). After five days recovery of animals, injections of MORPHINE began and the 9th day, 55 minutes after first s.c. injection of MORPHINE, 1µ/2min of 1-(2-methoxypbeoyl)-4-[4-(2-pthalimmido) butyl] piperazine hydrobromidc (NAN-190) vehicle was injected into the nuclei in the sham group. But in the test groups 1.5, 3.0 and 6.0 µg/µl/2min of NAN-190 (antagonist of 5-HT1A receptors) was injected Do the nuclei, and then naloxone was injected (i.p.).RESULTS: Data sips were analyzed by one way ANOVA and Tukey post test. The results this study showed a significant decrease in some of the recorded MORPHINE WITHDRAWAL sips (jumping p<0.05, writhing p<0.01 and wet-dog shakes p<0.001) in test groups in comparison with the control group. CONCLUSION: The results confirmed the important role of 5-HT1A receptors in raphe nucleuses on some of the MORPHINE WITHDRAWAL signs and may dissolve problems of opioides addiction.

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APA: Copy

CHARKHPOUR, M., & MOHAJEL NAEBI, ALI REZA. (2005). EVALUATION OF THE ROLE OF S-HT_1A RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT. PHARMACEUTICAL SCIENCES, -(3), 73-80. SID. https://sid.ir/paper/48542/en

Vancouver: Copy

CHARKHPOUR M., MOHAJEL NAEBI ALI REZA. EVALUATION OF THE ROLE OF S-HT_1A RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(3):73-80. Available from: https://sid.ir/paper/48542/en

IEEE: Copy

M. CHARKHPOUR, and ALI REZA MOHAJEL NAEBI, “EVALUATION OF THE ROLE OF S-HT_1A RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT,” PHARMACEUTICAL SCIENCES, vol. -, no. 3, pp. 73–80, 2005, [Online]. Available: https://sid.ir/paper/48542/en

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