EVALUATION OF THE ROLE OF5-HT2 RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT

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CHARKHPOUR M.; MOHAJEL NAEBI ALI REZA

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Journal: PHARMACEUTICAL SCIENCES Year:2006 | Volume:- | Issue:1 Page(s): 33-40

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Title

EVALUATION OF THE ROLE OF5-HT2 RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT

Author(s)

CHARKHPOUR M. | MOHAJEL NAEBI ALI REZA | Issue Writer Certificate

Keywords

5-HT2 RECEPTORSQ2

DORSAL RAPHE NUCLEUSQ2

MEDIAN RAPHE NUCLEUSQ2

MORPHINEQ2

WITHDRAWAL SYNDROMEQ2

Abstract

Objectives: The present study was performed to investigate the role of 5-HT2 receptors in dorsal and median raphe nuclei on the WITHDRAWAL SYNDROME of MORPHINE and accelerated the restraint of opioides. Methods: Experiments were performed on adult male wistar rats weighing between 225 and 275 g. The control group (n=8) had 9 days s.c. injections of MORPHINE (5, 10, 10, 15, 15, 20, 20, 25, 25mg/kg/12h) and the last day, 60 minutes after first injection of MORPHINE, 5mg/kg naloxone was injected (i.p.) and signs of WITHDRAWAL SYNDROME were recorded for 60 minutes. In the sham and test groups a guide cannula was implanted into the DRN and MRN in the separated groups (n=8). After five days recovery of animals, injections of MORPHINE began and the 9th day, 55 minutes after first s.c. injection of MORPHINE, 1ml/2min of a-Me-5HT vehicle was injected into the nuclei in the sham group. But in the test groups, 2.5, 5.0 and 10.0 mg/ml/2min of a-Me-5HT (agonist of 5-HT2 receptors) was injected into the nuclei, and then naloxone was injected (i.p.). Results: Data signs were analyzed by one way ANOVA and Tukey post test. The results of this study showed a significant decrease in some of the recorded MORPHINE withdrawal signs (for example for highest dose of a-Me- 5HT in DRN: jumping p<0.05, teeth chattering p<0.01, wet-dog shakes p<0.001 and genital grooming p<0.05) in test groups in comparisons with the control group. Conclusion: The results confirmed the important role of 5-HT2 receptors in raphe nucleuses on some of the MORPHINE withdrawal signs and may dissolve problems of opioides addiction.

Cites

EVALUATION OF THE ROLE OF5-HT2 RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT

References

EVALUATION OF THE ROLE OF5-HT2 RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT

Cite

APA: Copy

CHARKHPOUR, M., & MOHAJEL NAEBI, ALI REZA. (2006). EVALUATION OF THE ROLE OF5-HT₂ RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT. PHARMACEUTICAL SCIENCES, -(1), 33-40. SID. https://sid.ir/paper/48498/en

Vancouver: Copy

CHARKHPOUR M., MOHAJEL NAEBI ALI REZA. EVALUATION OF THE ROLE OF5-HT₂ RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT. PHARMACEUTICAL SCIENCES[Internet]. 2006;-(1):33-40. Available from: https://sid.ir/paper/48498/en

IEEE: Copy

M. CHARKHPOUR, and ALI REZA MOHAJEL NAEBI, “EVALUATION OF THE ROLE OF5-HT₂ RECEPTORS IN DORSAL AND MEDIAN RAPHE NUCLEI ON THE MORPHINE WITHDRAWAL SYNDROME IN RAT,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 33–40, 2006, [Online]. Available: https://sid.ir/paper/48498/en

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