DISSOLUTION ENHANCEMENT OF INDOMETHACIN BY SOLID DISPERSIONS PREPARED WITH POLYETHYLENE GLYCOLES OF DIFFERENT MOLECULAR WEIGHTS

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VALIZADEH H.; MONAJEMZADEH F.; NOKHOUDCHI A.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:3 Page(s): 65-72

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Title

DISSOLUTION ENHANCEMENT OF INDOMETHACIN BY SOLID DISPERSIONS PREPARED WITH POLYETHYLENE GLYCOLES OF DIFFERENT MOLECULAR WEIGHTS

Author(s)

VALIZADEH H. | MONAJEMZADEH F. | NOKHOUDCHI A. | Issue Writer Certificate

Keywords

INDOMETHACINQ2

SOLID DISPERSIONQ2

X-RAY DIFFRACTIONQ2

FT-IR SPECTROSCOPYQ2

Abstract

OBJECTIVES: This study was designed to increase the dissolution rate of poorly water soluble anti rheumatic agent, INDOMETHACIN, preparing SOLID DISPERSION with different with polyethylene glycoles of different molecular weights, and to study the mechanism of enhanced dissolution properties. Methods: PPEG2000, PEG4000, PEG6000 and PEG20000 were used as carriers and the SOLID DISPERSIONs were prepared by modified solvent method. Evaluation of SOLID DISPERSION properties was performed using solubility measurements, dissolution studies, Fourier-transform infrared spectroscopy and X-ray powder diffractometery (PXRD). Result: The results from solubility measurement indicated that, the solubility of INDOMETHACIN increased as the concentration and the molecular weight of PEG increased. The dissolution data revealed that these carriers can enhance the in vitro dissolution rate of INDOMETHACIN in both SGF (Simulated Gastric Fluid) and SIP (Simulated Gastric Fluid) media. The results of infrared spectroscopy together with those from X-RAY DIFFRACTION showed no drug-carrier interactions and INDOMETHACIN was still detectable in its solid state in all SOLID DISPERSIONs. Conclusion: An increased dissolution rate of INDOMETHACIN at pH 1.2 and 7.2 was observed when the drug was dispersed in these carriers. The solubilization effect of polyetbylene glycoles as well as the reduction of particle aggregation and an alteration of the surface properties of the drug particles might be responsible for the enhanced dissolution rate.

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APA: Copy

VALIZADEH, H., MONAJEMZADEH, F., & NOKHOUDCHI, A.. (2005). DISSOLUTION ENHANCEMENT OF INDOMETHACIN BY SOLID DISPERSIONS PREPARED WITH POLYETHYLENE GLYCOLES OF DIFFERENT MOLECULAR WEIGHTS. PHARMACEUTICAL SCIENCES, -(3), 65-72. SID. https://sid.ir/paper/48546/en

Vancouver: Copy

VALIZADEH H., MONAJEMZADEH F., NOKHOUDCHI A.. DISSOLUTION ENHANCEMENT OF INDOMETHACIN BY SOLID DISPERSIONS PREPARED WITH POLYETHYLENE GLYCOLES OF DIFFERENT MOLECULAR WEIGHTS. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(3):65-72. Available from: https://sid.ir/paper/48546/en

IEEE: Copy

H. VALIZADEH, F. MONAJEMZADEH, and A. NOKHOUDCHI, “DISSOLUTION ENHANCEMENT OF INDOMETHACIN BY SOLID DISPERSIONS PREPARED WITH POLYETHYLENE GLYCOLES OF DIFFERENT MOLECULAR WEIGHTS,” PHARMACEUTICAL SCIENCES, vol. -, no. 3, pp. 65–72, 2005, [Online]. Available: https://sid.ir/paper/48546/en

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