EFFECT OF GINSENOSIDE AS A PHYTOESTROGEN ON BUSULFAN-INDUCED DISORDERS IN SEMEN PARAMETER

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EBRAHIMI KALAN ABBAS; SOLEIMANIRAD J.; ROSHANGAR L.; KHAKI A.A.; MOHAMMADNEJAD D.

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Journal: PHARMACEUTICAL SCIENCES Year:2011 | Volume:17 | Issue:1 Page(s): 27-34

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Title

EFFECT OF GINSENOSIDE AS A PHYTOESTROGEN ON BUSULFAN-INDUCED DISORDERS IN SEMEN PARAMETER

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Keywords

INFERTILITYQ1

PHYTOESTROGENQ1

BUSULFANQ1

GINSENOSIDEQ1

Abstract

Objective: Destructive effect of BUSULFAN as an anticancer drug on spermatogenesis well known. it is recently proposed that estrogen has a role on spermatogenesis. The aim of the present study is to evaluate the effect of ginsinoside as a PHYTOESTROGEN on BUSULFAN-induced disorders on spermatogenesis.Methods: In the present study 50 balb-c mice were used and were kept under standard condition and were divided into five groups according to treatment with BUSULFAN and ginseng powder. After the experimental period, testes were dissected apart and semen was collected from quada epididymies and placed in Hams F10 medium and seminal parameters were evaluated and compared with control group.Results: The results showed that the number of sperms was significantly decreased after BUSULFAN. The other point is that the number of sperm between cases in BUSULFAN-treated group was variable. The number of sperm in ginseng receiving group increased comparison with BUSULFAN receiving group (31.25±3.93 vs 22.96±7.79). Percent of motility sperms in the BUSULFAN receiving group increased vs control group. This findings show that, probably sperm with rapid movement a few affected by BUSULFAN. Percent of normal morphology sperm in all groups were similar.Conclusions: The result indicates that GINSENOSIDE as a PHYTOESTROGEN of Ginseng prevent spermatogenesis defect after BUSULFAN injection.

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APA: Copy

EBRAHIMI KALAN, ABBAS, SOLEIMANIRAD, J., ROSHANGAR, L., KHAKI, A.A., & MOHAMMADNEJAD, D.. (2011). EFFECT OF GINSENOSIDE AS A PHYTOESTROGEN ON BUSULFAN-INDUCED DISORDERS IN SEMEN PARAMETER. PHARMACEUTICAL SCIENCES, 17(1), 27-34. SID. https://sid.ir/paper/48564/en

Vancouver: Copy

EBRAHIMI KALAN ABBAS, SOLEIMANIRAD J., ROSHANGAR L., KHAKI A.A., MOHAMMADNEJAD D.. EFFECT OF GINSENOSIDE AS A PHYTOESTROGEN ON BUSULFAN-INDUCED DISORDERS IN SEMEN PARAMETER. PHARMACEUTICAL SCIENCES[Internet]. 2011;17(1):27-34. Available from: https://sid.ir/paper/48564/en

IEEE: Copy

ABBAS EBRAHIMI KALAN, J. SOLEIMANIRAD, L. ROSHANGAR, A.A. KHAKI, and D. MOHAMMADNEJAD, “EFFECT OF GINSENOSIDE AS A PHYTOESTROGEN ON BUSULFAN-INDUCED DISORDERS IN SEMEN PARAMETER,” PHARMACEUTICAL SCIENCES, vol. 17, no. 1, pp. 27–34, 2011, [Online]. Available: https://sid.ir/paper/48564/en

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