MIDAZOLAM INFUSION IN TREATMENT OF PEDIATRIC REFRACTORY STATUS EPILEPTICUS

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BARZEGAR M.; RASHIDI M.R.; JAFARI ROUHI A.H.; JOUYBAN A.A.GH.; JABBARIBAR F.

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Journal: PHARMACEUTICAL SCIENCES Year:2004 | Volume:- | Issue:1 Page(s): 71-78

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Title

MIDAZOLAM INFUSION IN TREATMENT OF PEDIATRIC REFRACTORY STATUS EPILEPTICUS

Author(s)

Keywords

STATUS EPLIEPTICUSQ3

REFRACTORY STATUS EPILEPTICUSQ3

MIDAZOLAMQ2

Abstract

Status epileptic us is a serious life-threatening emergency in pediatric patients. Although initial therapies with agents such as diazepam, phenytoin or phenobarbital generally terminate seizure activity within 30-60 minutes, patients with refractory. status epilepticus lasting longer require additional intervention. MIDAZOLAM infusion may act as a safe and effective treatment in these patients. MIDAZOLAM (0.15 mg/kg intravenous bolus followed by 1-5 µg/kg/min infusion) was tried as treatment for 15 children with REFRACTORY STATUS EPILEPTICUS in Tabriz childrens Medical Center. History and physical examination were recorded. Serum electrolytes, urea, creatinin, liver function tests and blood gases were measured before and 24 hours after beginning of treatment. Brain computerized tomography scan and electroencephalography were carried out after stabilization of patients condition. Level of consciousness, respiratory rate, heart rate, blood pressure and arterial oxygen saturation have been recorded during treatment. The required amounts of MIDAZOLAM and the time to control each seizure attack were also determined. Phenytion and phenobarbital serum levels were measured before beginning of MIDAZOLAM infusion. The seizures were controlled in 11 (73.3%) patients completely. The average required time for complete cessation of seizure attack was 27.9 minutes. The mean infusion rate was 2.18 µg/kg/min. The serum level of phenytion and phenobarbital. was not less than 10 µg/ml in any patients. MIDAZOLAM infusion was discontinued in one patient because of need to mechanical ventilation due to respiratory suppression. No patient developed metabolic or electrolyte disturbance. There was no hypotension. MIDAZOLAM intravenous infusion, therefore, could be recommended as an effective and relatively safe treatment for refractory status epileptics.

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References

TREATMENTOF REFRACTORY CONVULSIVE STATUS EPILEPTICUS WITH CONTINUOUS MIDAZOLAM INFUSION

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APA: Copy

BARZEGAR, M., RASHIDI, M.R., JAFARI ROUHI, A.H., JOUYBAN, A.A.GH., & JABBARIBAR, F.. (2004). MIDAZOLAM INFUSION IN TREATMENT OF PEDIATRIC REFRACTORY STATUS EPILEPTICUS. PHARMACEUTICAL SCIENCES, -(1), 71-78. SID. https://sid.ir/paper/48577/en

Vancouver: Copy

BARZEGAR M., RASHIDI M.R., JAFARI ROUHI A.H., JOUYBAN A.A.GH., JABBARIBAR F.. MIDAZOLAM INFUSION IN TREATMENT OF PEDIATRIC REFRACTORY STATUS EPILEPTICUS. PHARMACEUTICAL SCIENCES[Internet]. 2004;-(1):71-78. Available from: https://sid.ir/paper/48577/en

IEEE: Copy

M. BARZEGAR, M.R. RASHIDI, A.H. JAFARI ROUHI, A.A.GH. JOUYBAN, and F. JABBARIBAR, “MIDAZOLAM INFUSION IN TREATMENT OF PEDIATRIC REFRACTORY STATUS EPILEPTICUS,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 71–78, 2004, [Online]. Available: https://sid.ir/paper/48577/en

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