LEVELS OF COPPER, ZINC AND SELENIUM IN SERUM AND TUMOR CYTOSOL EXTRACTS IN BREAST CANCER PATIENT

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ZARGHAMI N.A.; ASADI J.; MOHAMMADZADEH GH.; ASADI Y.

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Journal: PHARMACEUTICAL SCIENCES Year:2008 | Volume:- | Issue:3 Page(s): 41-48

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Title

LEVELS OF COPPER, ZINC AND SELENIUM IN SERUM AND TUMOR CYTOSOL EXTRACTS IN BREAST CANCER PATIENT

Author(s)

ZARGHAMI N.A. | ASADI J. | MOHAMMADZADEH GH. | ASADI Y. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

ZNQ2

CU SELENIUMQ2

AND TUMOR CYTOSOLQ2

Abstract

objectives: BREAST CANCER is the most common cancer in women. The aim of this study was to compare the concentration of Zinc, Selenium and Copper in serum AND TUMOR CYTOSOL extracts of BREAST CANCER patients and controls.Methods: This cross sectional study was composed of 50 women diagnosed with BREAST CANCER and 50 control individuals. Tissue samples were obtained from 32 women diagnosed with BREAST CANCER and 24 normal individuals. Serum and cytosol extract levels of ZN, Cu and selenium were measured by using atomic absorption spectrophotometry with Graphite furnace.Results: The Mean serum levels of ZN, Cu and Se in BREAST CANCER patients were 0.969±.19, 1.47±.48 mg/Land 60.04±23.38mg/L, respectively. The mean serum levels of ZN, Cu and Se in normal individual were 1.07±.35, 1.09±.20 mg/L and 92.42±18.70 mg/L, respectively. There was not significant difference in the mean of ZN between two groups but there was a significant difference in the mean of Cu between two groups (P<0.002). The ratio of Cu/Zn in BREAST CANCER patient and controls were 1.52 and 1.12, respectively. This difference was statistically significant (P<0.001). There was a significant difference in serum levels of Se between patients (92.42 ±18.7 mg/L) and controls (60.30 ± 23.38 mg/L) (P<0.001). The Mean cytosol levels of ZN in BREAST CANCER patients and controls were 66.75±72.5 and 28.29±3.84 mg/g, respectively and this difference was significant (P< 0.006). There was a significant difference in cytosol levels of Cu between patients (28.29 ± 3.8 mg/gr) and controls (21.02 ± 6.08) (P<0.002). The ratio of Cu/Zn in patients and controls were 0.42 and 0.79, respectively. This difference was statistically significant (P<0.000). In addition, there was a significant difference in cytosol levels of Se between patient (1.01±0.42 mg/gr) and control subjects (0.51±0.22 mg/gr) (P<0.01).Conclusion: Based on the obtained results, it is speculated that changes of serum and cytosolic levels of Se, ZN and Cu traces in BREAST CANCER patients could have important and biological roles in BREAST CANCER progression.

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APA: Copy

ZARGHAMI, N.A., ASADI, J., MOHAMMADZADEH, GH., & ASADI, Y.. (2008). LEVELS OF COPPER, ZINC AND SELENIUM IN SERUM AND TUMOR CYTOSOL EXTRACTS IN BREAST CANCER PATIENT. PHARMACEUTICAL SCIENCES, -(3), 41-48. SID. https://sid.ir/paper/48612/en

Vancouver: Copy

ZARGHAMI N.A., ASADI J., MOHAMMADZADEH GH., ASADI Y.. LEVELS OF COPPER, ZINC AND SELENIUM IN SERUM AND TUMOR CYTOSOL EXTRACTS IN BREAST CANCER PATIENT. PHARMACEUTICAL SCIENCES[Internet]. 2008;-(3):41-48. Available from: https://sid.ir/paper/48612/en

IEEE: Copy

N.A. ZARGHAMI, J. ASADI, GH. MOHAMMADZADEH, and Y. ASADI, “LEVELS OF COPPER, ZINC AND SELENIUM IN SERUM AND TUMOR CYTOSOL EXTRACTS IN BREAST CANCER PATIENT,” PHARMACEUTICAL SCIENCES, vol. -, no. 3, pp. 41–48, 2008, [Online]. Available: https://sid.ir/paper/48612/en

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