EVALUATION THE ANTINOCICEPTION EFFECT OF CHRONIC USE OF BUSPIRONE AND EFFECT OF THAT IN TOLERANCE TO MORPHINE ANALGESIA IN MICE

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CHARKHPOUR M.; MOHAJEL NAEBI ALI REZA; SHIVA A.

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Journal: PHARMACEUTICAL SCIENCES Year:2007 | Volume:- | Issue:4 Page(s): 35-42

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Title

EVALUATION THE ANTINOCICEPTION EFFECT OF CHRONIC USE OF BUSPIRONE AND EFFECT OF THAT IN TOLERANCE TO MORPHINE ANALGESIA IN MICE

Author(s)

CHARKHPOUR M. | MOHAJEL NAEBI ALI REZA | SHIVA A. | Issue Writer Certificate

Keywords

BUSPIRONEQ2

5-HT1A RECEPTORSQ2

D2 RECEPTORSQ2

MORPHINEQ2

TOLERANCEQ2

ANALGESIAQ2

Abstract

Objectives: Several studies indicate that central serotonergic neurons have important role in MORPHINE ANALGESIA and TOLERANCE. The aim of this study was to investigate possible role of 5-HT1A receptors by chronic administration of BUSPIRONE (partial agonist of 5- HT1A receptors) in producing analgesic effect and on development of TOLERANCE to analgesic effect of MORPHINE using hot plate test.Methods: Experiments were performed on adult male mice weighing between 20 and 25 g. The control mice (n=8) had daily i.p. injection of MORPHINE (5mg/kg/day). In the vehicle and test groups before injection of MORPHINE (5mg/kg/day, i.p.), we injected vehicle of BUSPIRONE (saline normal: 0.5 ml/kg/day, i.p.) and BUSPIRONE (5, 7.5 and 10 mg/kg/day, i.p.) respectively and the hot-plate test just before and 30 minutes after the MORPHINE injection performed once every 5 days. Experiments were continued for 5 days after the attainment of TOLERANCE to analgesic effect of MORPHINE. In the another three groups, we injected only BUSPIRONE (5, 7.5 and 10 mg/kg/day, i.p.) and the hot-plate test just before and 30 minutes after the BUSPIRONE injection performed once every 5 days for the evaluation of the analgesic effect of BUSPIRONE in chronic uses.Results: Chronic injection of BUSPIRONE (5, 7.5 and 10 mg/kg/day, i.p.) significantly delayed TOLERANCE to MORPHINE ANALGESIA (p<0.05). In addition, chronic administration of BUSPIRONE (5, 7.5 and 10 mg/kg/day, i.p.) produce significant analgesic effect (p<0.05).Conclusion: The results confirmed the important role of 5-HT1A receptors in ANALGESIA and the development of TOLERANCE to MORPHINE and may dissolve clinical problems due to long duration of opioides administration. However, the exact mechanism of interaction between serotonergic and opioidergic systems is not clear and remains to be elucidated.

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APA: Copy

CHARKHPOUR, M., MOHAJEL NAEBI, ALI REZA, & SHIVA, A.. (2007). EVALUATION THE ANTINOCICEPTION EFFECT OF CHRONIC USE OF BUSPIRONE AND EFFECT OF THAT IN TOLERANCE TO MORPHINE ANALGESIA IN MICE. PHARMACEUTICAL SCIENCES, -(4), 35-42. SID. https://sid.ir/paper/48621/en

Vancouver: Copy

CHARKHPOUR M., MOHAJEL NAEBI ALI REZA, SHIVA A.. EVALUATION THE ANTINOCICEPTION EFFECT OF CHRONIC USE OF BUSPIRONE AND EFFECT OF THAT IN TOLERANCE TO MORPHINE ANALGESIA IN MICE. PHARMACEUTICAL SCIENCES[Internet]. 2007;-(4):35-42. Available from: https://sid.ir/paper/48621/en

IEEE: Copy

M. CHARKHPOUR, ALI REZA MOHAJEL NAEBI, and A. SHIVA, “EVALUATION THE ANTINOCICEPTION EFFECT OF CHRONIC USE OF BUSPIRONE AND EFFECT OF THAT IN TOLERANCE TO MORPHINE ANALGESIA IN MICE,” PHARMACEUTICAL SCIENCES, vol. -, no. 4, pp. 35–42, 2007, [Online]. Available: https://sid.ir/paper/48621/en

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