SYNTHESIS AND ANALYSIS OF SOME NOVEL DERIVATIVES OF ANTHRAQUINONES FOR THE TREATMENT OF BREAST CANCER

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SADEGHI ALIABADI H.; MOHAMMADI V.; JAFARIAN DEHKORDI ABAS

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Journal: PHARMACEUTICAL SCIENCES Year:2003 | Volume:- | Issue:2 Page(s): 63-74

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Title

SYNTHESIS AND ANALYSIS OF SOME NOVEL DERIVATIVES OF ANTHRAQUINONES FOR THE TREATMENT OF BREAST CANCER

Author(s)

SADEGHI ALIABADI H. | MOHAMMADI V. | JAFARIAN DEHKORDI ABAS | Issue Writer Certificate

Keywords

ANTHRAQUINONESQ3

ANTICANCER DRUGSQ3

BREAST CANCERQ2

Abstract

Breast cancer is one of the most important types of cancer in pre- and post menopausal women. Chemotherapy is one of the most accepted strategies in the treatment of BREAST CANCER. Among chemotherapeutic agents, anthracyclines such as doxorubicin and its anthraquinone (AQ) analogues, mitoxantrone, are the most effective and cytotoxic compounds. The cytotoxicity of these compounds is based on their interaction with cellular DNA and RNA and also production of free hydroxyl radicals. It is believed that these compounds show a dose dependent cardiotoxicity, due to production of free radicals. In this study we tried to synthesis new ANTHRAQUINONES with less cardiotoxicity. To synthesize AQ derivatives 1-Chloro-AQ was refluxed with 3-amino-1-propanol in n-butanol to give 1[N- (3-hydroxypropyl) amino] AQ. This compound was then reacted with methansulfonylchloride in pyridine at room temprature to produce an intermediate compound. Finally this compound was refluxed with 1,3-diaminopropane in acetonitril to give 1-[N-(N' - (3-aminopropyl)3 aminopropyl]amino]AQ. In another attempt, l-chloroAQ was reacted with 1,3-diaminopropan at 50º.C to give l-[N- (3-aminopropyl) amino-AQ. In this study three compounds were synthesized and their structures were confirmed using, melting point, IR, IH NMR and Mass spectra. Synthesized compounds are AQ anticancer analogues that have one or two side chain with 4 to 8 atoms length. They, therefore, probably will effect against cancer cells by intercalation with DNA or produce hydroxyl free radicals to cause cell death.

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APA: Copy

SADEGHI ALIABADI, H., MOHAMMADI, V., & JAFARIAN DEHKORDI, ABAS. (2003). SYNTHESIS AND ANALYSIS OF SOME NOVEL DERIVATIVES OF ANTHRAQUINONES FOR THE TREATMENT OF BREAST CANCER. PHARMACEUTICAL SCIENCES, -(2), 63-74. SID. https://sid.ir/paper/48656/en

Vancouver: Copy

SADEGHI ALIABADI H., MOHAMMADI V., JAFARIAN DEHKORDI ABAS. SYNTHESIS AND ANALYSIS OF SOME NOVEL DERIVATIVES OF ANTHRAQUINONES FOR THE TREATMENT OF BREAST CANCER. PHARMACEUTICAL SCIENCES[Internet]. 2003;-(2):63-74. Available from: https://sid.ir/paper/48656/en

IEEE: Copy

H. SADEGHI ALIABADI, V. MOHAMMADI, and ABAS JAFARIAN DEHKORDI, “SYNTHESIS AND ANALYSIS OF SOME NOVEL DERIVATIVES OF ANTHRAQUINONES FOR THE TREATMENT OF BREAST CANCER,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 63–74, 2003, [Online]. Available: https://sid.ir/paper/48656/en

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