EFFECT OF HYDRO ALCOHOLIC EXTRACT OF PEEL OF PUNICA GRANATUM ON EXPERIMENTAL DIABETES MELLITUS BY STREPTOZOTOCIN IN RATS

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NAJAFZADEH H.; AGHEL N.; HEMMATI A.A.; OULAPOUR S.

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Journal: PHARMACEUTICAL SCIENCES Year:2011 | Volume:16 | Issue:4 Page(s): 239-248

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Information Journal Paper

Title

EFFECT OF HYDRO ALCOHOLIC EXTRACT OF PEEL OF PUNICA GRANATUM ON EXPERIMENTAL DIABETES MELLITUS BY STREPTOZOTOCIN IN RATS

Author(s)

NAJAFZADEH H. | AGHEL N. | HEMMATI A.A. | OULAPOUR S. | Issue Writer Certificate

Keywords

PEEL EXTRACT OF PUNICA GRANATUMQ1

BLOOD GLUCOSEQ1

INSULINQ1

DIABETESQ2

RATQ2

Abstract

Objectives: Punica granatum L. (pomegranate) is a widely used plant that has high nutritional value. The aim of this study was to assess the effect of administration of pomegranate peel extract (PPE) on BLOOD GLUCOSE in diabetic RATs.Methods: The hydro alcoholic extract was achieved by maceration method from peel of pomegranate. Six groups of RATs received streptozotocin and the BLOOD GLUCOSE was determined 8 days later for DIABETES mellitus. One group of diabetic RATs received glibenclamide and 3 groups received extract at dose 200, 400 and 600 mg/kg irnterapritoneally and one group received the extract at dose 600mg/kg orally; one group was kept as control. The serum INSULIN was measured by kit. The BLOOD GLUCOSE was measured by glucometer at 1, 2, 3 and 24 hours after drug administration.Results: The results showed the pomegranate peel extract had significantly better glucose lowering effect at dose 200 mg/kg (IP) and 600mg/kg orally (p<0.05). Also PPE had significantly regulated INSULIN at dose 600 mg/kg.Conclusion: This study shows beneficial antidiabetic effect of PPE.

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APA: Copy

NAJAFZADEH, H., AGHEL, N., HEMMATI, A.A., & OULAPOUR, S.. (2011). EFFECT OF HYDRO ALCOHOLIC EXTRACT OF PEEL OF PUNICA GRANATUM ON EXPERIMENTAL DIABETES MELLITUS BY STREPTOZOTOCIN IN RATS. PHARMACEUTICAL SCIENCES, 16(4), 239-248. SID. https://sid.ir/paper/48692/en

Vancouver: Copy

NAJAFZADEH H., AGHEL N., HEMMATI A.A., OULAPOUR S.. EFFECT OF HYDRO ALCOHOLIC EXTRACT OF PEEL OF PUNICA GRANATUM ON EXPERIMENTAL DIABETES MELLITUS BY STREPTOZOTOCIN IN RATS. PHARMACEUTICAL SCIENCES[Internet]. 2011;16(4):239-248. Available from: https://sid.ir/paper/48692/en

IEEE: Copy

H. NAJAFZADEH, N. AGHEL, A.A. HEMMATI, and S. OULAPOUR, “EFFECT OF HYDRO ALCOHOLIC EXTRACT OF PEEL OF PUNICA GRANATUM ON EXPERIMENTAL DIABETES MELLITUS BY STREPTOZOTOCIN IN RATS,” PHARMACEUTICAL SCIENCES, vol. 16, no. 4, pp. 239–248, 2011, [Online]. Available: https://sid.ir/paper/48692/en

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