SUSCEPTIBILITY OF MYCOBACTERIUM TUBERCULOSIS AND NONTUBERCULOUS MYCOBACTERIA TO KANAMAYCIN AND AMIKACIN

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MOADAB SEYED REZA; RAFI A.A.N.

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Journal: PHARMACEUTICAL SCIENCES Year:2006 | Volume:- | Issue:4 Page(s): 47-54

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Information Journal Paper

Title

SUSCEPTIBILITY OF MYCOBACTERIUM TUBERCULOSIS AND NONTUBERCULOUS MYCOBACTERIA TO KANAMAYCIN AND AMIKACIN

Author(s)

MOADAB SEYED REZA | RAFI A.A.N. | Issue Writer Certificate

Keywords

MYCOBACTERIUM TUBERCULOSISQ2

NONTUBERCULOUS MYCOBACTERIAQ2

DRUG RESISTANCEQ2

KANAMYCINQ2

AMIKACINQ1

Abstract

Objectives: The evaluation of effectiveness of second line agents against mycobacterial isolates has become more important in the past few years predominantly due to the appearance of multi drug - resistant tuberculosis. The aim of this study was to investigate the in vitro susceptibility of resistant M. tuberculosis (MT) and NONTUBERCULOUS MYCOBACTERIA (NTM) to some second line anti - mycobacterial agents. Methods: In this study, in-vitro activity of KANAMYCIN and AMIKACIN against 90 MT and 10 NTM strains were investigated by proportional method. Results: Of 90 MT strains, 40 isolates were found to be resistant and 50 isolates were susceptible to first line drugs. All of 10 NTM strains were found to be resistant to first line drugs. H37RV MT (susceptible to all drugs) was used as a control. Of 90 M. tuberculosis isolates, %13 of strains was found to be resistant to KANAMYCIN and %5 of strains was resistant to AMIKACIN. Of 90 MT isolates, 29 strains were resistant to streptomycin, 8 strains to KANAMYCIN and 3 strains were found to be resistant to AMIKACIN. Of 10 NTM isolates, 8 strains were resistant to KANAMYCIN and AMIKACIN. Conclusion: These findings show the usefulness of AMIKACIN and KANAMYCIN in the treatment of resistant tuberculosis in MT strains. Studies such as this investigation should be conducted regularly in order to help effectively TB control efforts.

Cites

DRUG SUSCEPTIBILITY PATTERN OF MYCOBACTERIUM TUBERCULOSIS STRAINS TO FIRST AND SECOND LINE DRUGS IN TABRIZ, IRAN

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APA: Copy

MOADAB, SEYED REZA, & RAFI, A.A.N.. (2006). SUSCEPTIBILITY OF MYCOBACTERIUM TUBERCULOSIS AND NONTUBERCULOUS MYCOBACTERIA TO KANAMAYCIN AND AMIKACIN. PHARMACEUTICAL SCIENCES, -(4), 47-54. SID. https://sid.ir/paper/48740/en

Vancouver: Copy

MOADAB SEYED REZA, RAFI A.A.N.. SUSCEPTIBILITY OF MYCOBACTERIUM TUBERCULOSIS AND NONTUBERCULOUS MYCOBACTERIA TO KANAMAYCIN AND AMIKACIN. PHARMACEUTICAL SCIENCES[Internet]. 2006;-(4):47-54. Available from: https://sid.ir/paper/48740/en

IEEE: Copy

SEYED REZA MOADAB, and A.A.N. RAFI, “SUSCEPTIBILITY OF MYCOBACTERIUM TUBERCULOSIS AND NONTUBERCULOUS MYCOBACTERIA TO KANAMAYCIN AND AMIKACIN,” PHARMACEUTICAL SCIENCES, vol. -, no. 4, pp. 47–54, 2006, [Online]. Available: https://sid.ir/paper/48740/en

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