EFFECT OF POTASSIUM CHANNEL BLOCKER TETRAETHYLAMMONIUM PRETREATMENT ON PREVENTION OF THE 6-OHDA-INDUCED CHRONIC PARKINSON'S DISEASE IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAGHDOOST YAZDI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Inflammatory Diseases Year:2016 | Volume:20 | Issue:2 (85) Page(s): 41-48

Download Full-Text

Persian Verion

View:

1,801

Download:

Cites:

Information Journal Paper

Title

EFFECT OF POTASSIUM CHANNEL BLOCKER TETRAETHYLAMMONIUM PRETREATMENT ON PREVENTION OF THE 6-OHDA-INDUCED CHRONIC PARKINSON'S DISEASE IN RATS

Author(s)

Keywords

POTASSIUM CHANNELSQ1

TETRAETHYLAMMONIUMQ2

OXIDOPAMINEQ1

SUBSTANTIA NIGRAQ2

Abstract

Background: Nuclease and caspase activities that promote death signals and cause apoptosis are dependent to potassium ion.Objective: The aim of this study was to investigate the effect of potassium channel blocker TETRAETHYLAMMONIUM (TEA) on prevention of Parkinson's disease in rats.Methods: This experimental study was conducted on 33 male rats in Qazvin University of Medical Sciences, 2014.6-hydroxydopamine (6-OHDA) was injected into the striatum of the brain. The rats received different doses of TEA twice daily the day before the 6-OHDA injection till 15 days after the injection. The severity of Parkinsonism was assessed by the apomorphine-induced rotational behavior, the elevated body swing test (EBST), and the rotarod test. Data were analyzed using Kruskal Wallis and Mann Whitney U tests.Findings: Pretreatment with 5 mg/kg TEA significantly reduced the severity of rotations compared to the saline group. TEA did not reduce the swings in the EBST. In the rotarod test, TEA caused significant improvement in the motor performance of the rats.Conclusion: With regards to the results, it seems that pretreatment with TEA can partly reduce the severity of behavioral symptoms in the 6-OHDA-induced chronic Parkinson's disease. The higher the TEA dose, the more significant the reduction in the severity of symptoms.

Cites

No record.

References

No record.

Cite

APA: Copy

HAGHDOOST YAZDI, H.. (2016). EFFECT OF POTASSIUM CHANNEL BLOCKER TETRAETHYLAMMONIUM PRETREATMENT ON PREVENTION OF THE 6-OHDA-INDUCED CHRONIC PARKINSON'S DISEASE IN RATS. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 20(2 (85)), 41-48. SID. https://sid.ir/paper/48826/en

Vancouver: Copy

HAGHDOOST YAZDI H.. EFFECT OF POTASSIUM CHANNEL BLOCKER TETRAETHYLAMMONIUM PRETREATMENT ON PREVENTION OF THE 6-OHDA-INDUCED CHRONIC PARKINSON'S DISEASE IN RATS. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2016;20(2 (85)):41-48. Available from: https://sid.ir/paper/48826/en

IEEE: Copy

H. HAGHDOOST YAZDI, “EFFECT OF POTASSIUM CHANNEL BLOCKER TETRAETHYLAMMONIUM PRETREATMENT ON PREVENTION OF THE 6-OHDA-INDUCED CHRONIC PARKINSON'S DISEASE IN RATS,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 20, no. 2 (85), pp. 41–48, 2016, [Online]. Available: https://sid.ir/paper/48826/en

Related Journal Papers