THE EXPRESSION OF E-CADHERIN IN ORAL SQUAMOUS CELL CARCINOMA AND ITS CORRELATION WITH HISTOPATHOLOGIC VARIABLES

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GHAFARZADEGAN KAMRAN; SETAREH A.; SHAKERI M.T.; SINA M.

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Journal: IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY Year:2005 | Volume:17 | Issue:1 (39) Page(s): 70-76

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Title

THE EXPRESSION OF E-CADHERIN IN ORAL SQUAMOUS CELL CARCINOMA AND ITS CORRELATION WITH HISTOPATHOLOGIC VARIABLES

Author(s)

GHAFARZADEGAN KAMRAN | SETAREH A. | SHAKERI M.T. | SINA M. | Issue Writer Certificate

Keywords

ORAL SQUAMOUS CELL CARCINOMA-E-CADHERIN-IMMUNOHISTOCHEMISTRY-HISTOPATHOLOGIC VARIABLESQ3

Abstract

Aims: E-Cadherin is a cell-cell adhesion molecule involved in tumor progression and metastasis. We evaluated the E-Cadherin expression pattern in oral SCC and investigated its relationship to histopathological features. Methods: The expression of E-Cadherin was evaluated in 43 formalin-fixed, paraffin-embedded specimens of oral SCC by immunohistochemistry. Results: In normal squamous epithelium, E-Cadherin was expressed uniformly at the cell membrane. Abnormal E-Cadherin expression with loss of membranous localization was found in 62.8% cancer specimens. We used a scoring system for semiquantitative comparison of results. Altered E-Cadherin expression was found more often in higher grades than in lower grades (p=0.000) There was not any significant correlation between E-cadherin expression and muscular invasion (P>0.1). There was not significant correlation between sex and E-cadherin expression. Conclusions: Abnormal expression of E-Cadherin occurs frequently in oral squamous cell carcinoma and correlates with dedifferentiation of tUf!"lors. Moreover, E-Cadherin expression is not associated with muscular invasion. We concluded that loss of normal E-Cadherin expression might serve as a differentiation marker in oral squamous cell carcinoma. short running title: E-Cadherin Expression in Oral SCC.

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APA: Copy

GHAFARZADEGAN, KAMRAN, SETAREH, A., SHAKERI, M.T., & SINA, M.. (2005). THE EXPRESSION OF E-CADHERIN IN ORAL SQUAMOUS CELL CARCINOMA AND ITS CORRELATION WITH HISTOPATHOLOGIC VARIABLES. IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, 17(1 (39)), 70-76. SID. https://sid.ir/paper/49380/en

Vancouver: Copy

GHAFARZADEGAN KAMRAN, SETAREH A., SHAKERI M.T., SINA M.. THE EXPRESSION OF E-CADHERIN IN ORAL SQUAMOUS CELL CARCINOMA AND ITS CORRELATION WITH HISTOPATHOLOGIC VARIABLES. IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY[Internet]. 2005;17(1 (39)):70-76. Available from: https://sid.ir/paper/49380/en

IEEE: Copy

KAMRAN GHAFARZADEGAN, A. SETAREH, M.T. SHAKERI, and M. SINA, “THE EXPRESSION OF E-CADHERIN IN ORAL SQUAMOUS CELL CARCINOMA AND ITS CORRELATION WITH HISTOPATHOLOGIC VARIABLES,” IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, vol. 17, no. 1 (39), pp. 70–76, 2005, [Online]. Available: https://sid.ir/paper/49380/en

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