DIAGNOSTIC VALUE OF AGNOR STAINING IN NEOPLASTIC AND NON NEOPLASTIC LESIONS OF THYROID

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AYAT ELAHI HOSSEIN; SHARIFI N.; KALANTARI M.R.; OMIDI A.

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Title

DIAGNOSTIC VALUE OF AGNOR STAINING IN NEOPLASTIC AND NON NEOPLASTIC LESIONS OF THYROID

Author(s)

AYAT ELAHI HOSSEIN | SHARIFI N. | KALANTARI M.R. | OMIDI A. | Issue Writer Certificate

Keywords

THYROIDQ3

NEOPLASMSQ3

NON NEOPLASTIC LESIONQ3

AGNORQ3

Abstract

Background: The aim of this study was to determine the value of the argyrophilic nucleolar organizer region (AGNOR) . as a proliferative marker in neoplastic and non-neoplastic lesions of the THYROID i-r Methods: AGNOR count were evaluated in paraffn. Embeded tissue of resection specimens of the THYROID from 100 patients was retrieved from files of the Pathology Department of the Ghaem Hospital Medical Center including: Normal THYROID gland (N=8) Nadular Goiter (N=19) Follicular Adenoma (N=34) Follicular carcinoma (N=10) Medullary carcinoma (N= 4) Papillary carcinoma (N=15) Anaplastic carcinoma (N= 4) THYROIDitis (N=6) The investigated parameters included the number, size, shape and localization of AGNOR dots in nucleoli of hundred cells and percentage of nucleoli with at least 3 and 5 or more AGNOR dots per cell (distribution score). Results: The mean AGNOR dots and 3 A dot per cell were statistically signifi tf cantly higher in malignant lesions in comparison to benign lesions. No clear separation statically between groups about parameter 5 or more dots per cells. Total discrimination between follicular adenoma and carcinoma was achieved by quantification of AGNOR dot tumor uncleolous cell (AGNOR distribution score) Conclusion: The AGNOR and AGNOR distribution score proved to be the most valuable diagnostic criterion for the differentiation between follicular adenoma and carcinoma of the THYROID.

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APA: Copy

AYAT ELAHI, HOSSEIN, SHARIFI, N., KALANTARI, M.R., & OMIDI, A.. (2005). DIAGNOSTIC VALUE OF AGNOR STAINING IN NEOPLASTIC AND NON NEOPLASTIC LESIONS OF THYROID. IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, 17(1 (39)), 28-34. SID. https://sid.ir/paper/49392/en

Vancouver: Copy

AYAT ELAHI HOSSEIN, SHARIFI N., KALANTARI M.R., OMIDI A.. DIAGNOSTIC VALUE OF AGNOR STAINING IN NEOPLASTIC AND NON NEOPLASTIC LESIONS OF THYROID. IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY[Internet]. 2005;17(1 (39)):28-34. Available from: https://sid.ir/paper/49392/en

IEEE: Copy

HOSSEIN AYAT ELAHI, N. SHARIFI, M.R. KALANTARI, and A. OMIDI, “DIAGNOSTIC VALUE OF AGNOR STAINING IN NEOPLASTIC AND NON NEOPLASTIC LESIONS OF THYROID,” IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, vol. 17, no. 1 (39), pp. 28–34, 2005, [Online]. Available: https://sid.ir/paper/49392/en

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