THE PROGNOSTIC VALUE OF KI-67 IMMUNOASSAYING IN MENINGIOMA

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BIRJANDY A.R.; MASHHADINEZHAD H.; RAFATEE A.R.

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Journal: IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY Year:2005 | Volume:17 | Issue:2 (40) Page(s): 39-47

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Title

THE PROGNOSTIC VALUE OF KI-67 IMMUNOASSAYING IN MENINGIOMA

Author(s)

BIRJANDY A.R. | MASHHADINEZHAD H. | RAFATEE A.R. | Issue Writer Certificate

Keywords

KI-67 INDICESQ3

MENINGIOMAQ3

ATYPICAL MENINGIOMAQ3

RECURRENCEQ3

PROGNOSISQ3

Abstract

Object: This study was designed to provide the relationship among labeling indices of ki-67, Helsinki grading, and tumor histopathology of MENINGIOMAs. Method: ki-67 staining by polyclonal was performed on twenty-nine formalin-fixed/ paraffin embedded tissues obtained from 29 MENINGIOMAs resected from 29 patients. The Helsinki grading and histopathology (classification of Russel and Rubistein) of tumour were reviewed by a pathologist.Results: There were 21 women and 8 men. The mean age of patients was 49.1 with range between 21 and 70 year. The most common presenting symptom was headache (16 patients, 55.1%). The most common presenting sign was papilledema (8 patients, 27.5%).The tumor was located most commonly on convexity (7 patients, 24.1%). There were 22 benign MENINGIOMAs (grade I Helsinki) and 7 atypical MENINGIOMAs (grade 11 Helsinki).Ki-67 was stained in 12 specimens; (71.14%) benign MENINGIOMAs and 5 atypical MENINGIOMAs. There were no differences between the two groups (p=0.192). The ki-67 labeling index was significantly lower in benign MENINGIOMAs than in atypical MENINGIOMAs (mean ki-67: 9.5 ±17.9 versus 31.8±28.4, p=0.02).The ki-67 labeling index was lower in meningothelial than transitional and fibroblastic MENINGIOMAs but it was not significant (the mean ki-67: 8.2±14.6 versus 18.6±26.7and 24± 28.8, p=0.27 and p=0.14). The log (ki-67) was higher than 1.2 in atypical MENINGIOMAs but was distributed evenly between 1.6 and 2.Conclusion: The ki-67 labeling index was significantly higher in atypical MENINGIOMAs. It may be a predictive value of aggressiveness in MENINGIOMAs and also shows the tendency of the tumor to RECURRENCE.

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APA: Copy

BIRJANDY, A.R., MASHHADINEZHAD, H., & RAFATEE, A.R.. (2005). THE PROGNOSTIC VALUE OF KI-67 IMMUNOASSAYING IN MENINGIOMA. IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, 17(2 (40)), 39-47. SID. https://sid.ir/paper/49447/en

Vancouver: Copy

BIRJANDY A.R., MASHHADINEZHAD H., RAFATEE A.R.. THE PROGNOSTIC VALUE OF KI-67 IMMUNOASSAYING IN MENINGIOMA. IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY[Internet]. 2005;17(2 (40)):39-47. Available from: https://sid.ir/paper/49447/en

IEEE: Copy

A.R. BIRJANDY, H. MASHHADINEZHAD, and A.R. RAFATEE, “THE PROGNOSTIC VALUE OF KI-67 IMMUNOASSAYING IN MENINGIOMA,” IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, vol. 17, no. 2 (40), pp. 39–47, 2005, [Online]. Available: https://sid.ir/paper/49447/en

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