CORRELATION OF LUPUS ACTIVITY BASED ON BRITISH ISLES LUPUS ASSESSMENT GROUP INDEX WITH SEROLOGIC MARKERS OF LUPUS ACTIVITY IN PATIENTS OF RHEUMATOLOGY CLINIC

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KARIMIFAR MANSOOR; SAYED BONAKDAR ZAHRA; NASIRI SIAVASH

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Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2010 | Volume:28 | Issue:111 Page(s): 563-570

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Title

CORRELATION OF LUPUS ACTIVITY BASED ON BRITISH ISLES LUPUS ASSESSMENT GROUP INDEX WITH SEROLOGIC MARKERS OF LUPUS ACTIVITY IN PATIENTS OF RHEUMATOLOGY CLINIC

Author(s)

KARIMIFAR MANSOOR | SAYED BONAKDAR ZAHRA | NASIRI SIAVASH | Issue Writer Certificate

Keywords

SYSTEMIC LUPUS ERYTHEMATOSUSQ3

ESRQ2

C3Q3

C4Q3

ANTI-DSDNAQ2

BILAG INDEXQ2

THE SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEXQ2

Abstract

Background: This study aimed to determine the correlation between of ESR, C3, C4, ANTI-DSDNA, and lupus activity and also the construct and criterion validity of the British Isles Lupus Assessment Group (BILAG) index for assessing disease activity in SYSTEMIC LUPUS ERYTHEMATOSUS (SLE).Methods: Patients with SLE were recruited into a cross-sectional study. Data were analyzed for estimating of SLE disease activity [scores on the BILAG INDEX and SYSTEMIC LUPUS ERYTHEMATOSUS Disease Activity Index 2000 (SLEDAI-2K)]. Overall BILAG scores were determined by the highest score achieved in any of the individual systems in the respective index. Erythrocyte sedimentation rates (ESRs), C3 levels, C4 levels, anti-double-stranded DNA (anti-ds DNA) levels, and SLEDAI-2K scores were used in the analysis of construct validity. Statistical analyses were performed using ordinal logistic regression for construct validity.Findings: Of the 100 patients with SLE, 90% were women. Their mean±SD age was 31.1±9.8 years. Increasing overall scores on the BILAG INDEX were associated with increasing ESR level, decreasing C3 levels, decreasing C4 levels, and elevated ANTI-DSDNA levels, and increasing SLEDAI-2K scores (all P<0.01).Conclusion: These findings showed that the ESR, C3, C4, and ANTI-DSDNA should be used in the evaluation and management of patients with SLE. Also the results show that the BILAG INDEX has construct validity.

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APA: Copy

KARIMIFAR, MANSOOR, SAYED BONAKDAR, ZAHRA, & NASIRI, SIAVASH. (2010). CORRELATION OF LUPUS ACTIVITY BASED ON BRITISH ISLES LUPUS ASSESSMENT GROUP INDEX WITH SEROLOGIC MARKERS OF LUPUS ACTIVITY IN PATIENTS OF RHEUMATOLOGY CLINIC. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 28(111), 563-570. SID. https://sid.ir/paper/49670/en

Vancouver: Copy

KARIMIFAR MANSOOR, SAYED BONAKDAR ZAHRA, NASIRI SIAVASH. CORRELATION OF LUPUS ACTIVITY BASED ON BRITISH ISLES LUPUS ASSESSMENT GROUP INDEX WITH SEROLOGIC MARKERS OF LUPUS ACTIVITY IN PATIENTS OF RHEUMATOLOGY CLINIC. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2010;28(111):563-570. Available from: https://sid.ir/paper/49670/en

IEEE: Copy

MANSOOR KARIMIFAR, ZAHRA SAYED BONAKDAR, and SIAVASH NASIRI, “CORRELATION OF LUPUS ACTIVITY BASED ON BRITISH ISLES LUPUS ASSESSMENT GROUP INDEX WITH SEROLOGIC MARKERS OF LUPUS ACTIVITY IN PATIENTS OF RHEUMATOLOGY CLINIC,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 28, no. 111, pp. 563–570, 2010, [Online]. Available: https://sid.ir/paper/49670/en

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