ANTIHYPERTENSIVE EFFECT OF LACTOFERRIN ON DEXAMETHASONE-INDUCED HYPERTENSION IN RAT

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SAFAEIAN LEILA; ZABOLIAN HADI

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Journal: Journal of Isfahan Medical School Year:2013 | Volume:31 | Issue:245 Page(s): 1096-1104

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Information Journal Paper

Title

ANTIHYPERTENSIVE EFFECT OF LACTOFERRIN ON DEXAMETHASONE-INDUCED HYPERTENSION IN RAT

Author(s)

SAFAEIAN LEILA | ZABOLIAN HADI | Issue Writer Certificate

Keywords

LACTOFERRINQ2

HYPERTENSIONQ2

GLUCOCORTICOIDQ3

Abstract

Background: Dexamethasone-induced HYPERTENSION is one of the animal models of HYPERTENSION. LACTOFERRIN is a natural iron-binding protein with proposed antihypertensive effects. In this study, the effect of chronic use of LACTOFERRIN was investigated on dexamethasone-induced HYPERTENSION in rat and compared with captopril.Methods: In this experimental study, HYPERTENSION was induced by subcutaneously injection of dexamethasone (30 ±g/kg/day) for 15 days in Wistar rat. LACTOFERRIN (300 mg/kg) and captopril (40 mg/kg) were orally given from the day 8 to 15. Systolic blood pressure was measured by tail cuff. Body weight was measured during experiment and thymus weight was detected as a marker of GLUCOCORTICOID activity at the end of study. Findings: Administration of dexamethasone increased systolic blood pressure (115.6+3.3 to 150.1+7.4 mmHg) and decreased body and thymus weight (P<0.05). Chronic administration of LACTOFERRIN and captopril for one week decreased systolic blood pressure (P<0.01 for both). LACTOFERRIN also prevented body weight loss.Conclusion: The results indicated antihypertensive effect of LACTOFERRIN on dexamethasone-induced HYPERTENSION. Further studies are suggested for finding the mechanism of LACTOFERRIN in this model of HYPERTENSION.

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APA: Copy

SAFAEIAN, LEILA, & ZABOLIAN, HADI. (2013). ANTIHYPERTENSIVE EFFECT OF LACTOFERRIN ON DEXAMETHASONE-INDUCED HYPERTENSION IN RAT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(245), 1096-1104. SID. https://sid.ir/paper/49775/en

Vancouver: Copy

SAFAEIAN LEILA, ZABOLIAN HADI. ANTIHYPERTENSIVE EFFECT OF LACTOFERRIN ON DEXAMETHASONE-INDUCED HYPERTENSION IN RAT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(245):1096-1104. Available from: https://sid.ir/paper/49775/en

IEEE: Copy

LEILA SAFAEIAN, and HADI ZABOLIAN, “ANTIHYPERTENSIVE EFFECT OF LACTOFERRIN ON DEXAMETHASONE-INDUCED HYPERTENSION IN RAT,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 245, pp. 1096–1104, 2013, [Online]. Available: https://sid.ir/paper/49775/en

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