DRUG RESISTANCE OF ISOLATED STRAINS OF MYCOBACTERIUM TUBERCULOSIS

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NADERI MOHAMMAD; NASERPOUR FARIVAR T.; KOUHPAYEH H.R.; OWEISI OSKOUIE H.

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Journal: Journal of Isfahan Medical School Year:2004 | Volume:21 | Issue:71 Page(s): 40-43

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Title

DRUG RESISTANCE OF ISOLATED STRAINS OF MYCOBACTERIUM TUBERCULOSIS

Author(s)

NADERI MOHAMMAD | NASERPOUR FARIVAR T. | KOUHPAYEH H.R. | OWEISI OSKOUIE H. | Issue Writer Certificate

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Abstract

Introduction: Prolonged required time for treatment, presence of primary resistant strains, changing or discontinuation of anti TB drugs before completion of therapy, presence of the underlying disease, changes in the life condition and the incidence of abnormal behavior such as alcoholism, homelessness, addiction, great migration, margination around big cities and AIDS, all have caused the incidence and dissemination of drug resistance strains as a serious danger Sistan and Baluchestan province regarding to its special cultural and economical condition and proximity to the countries with high prevalence of TB is at special risk for endemic situation of tuberculosis. So, this study was done for determination of drug resistancy of isolated strains to the first line of anti TB drugs (Isoniazid, Rifampin, Ethambutol and streptomycin) in mycobacterium tuberculosis strains isolated from patients referring to Bou-Ali hospital. Methods: All patients referring to Bou-Ali hospital in Zahedan during 2001-2002 which had a positive smear results with ZNCF staining methods. After primary culture and necessary subculturing on Lowenstein-Jensen medium and on the basis of growth rate, pigmentation and biochemical tests, Mycobacterium tuberculosis strains were identified and included in the study. Drug sensitivity tests of isolated strains without attention to their history (newly diagnosed or previously treated) were done by standard proportional method. Results: Study on the 84 Mycobacterium tuberculosis isolated strains from patients referred to bou-Ali hospital during 2001-2002,demonstrated resistance rate for RIM, INH, STM& EMB as 55.9%, 39.2%, 33.3% & 27.3% respectively. MDR strain rate was 16.6% polyresistant pattern rate was 38.09%. Discussion: Prevalence rate and extent of drug resistancy investigated between mycobacterium tuberculosis isolates showed that if fast and accurate attention to the drug resistance of isolated strains was not paid, an unavoidable increase in the distribution and prevalence of multiple drug resistant strains will be observed.

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APA: Copy

NADERI, MOHAMMAD, NASERPOUR FARIVAR, T., KOUHPAYEH, H.R., & OWEISI OSKOUIE, H.. (2004). DRUG RESISTANCE OF ISOLATED STRAINS OF MYCOBACTERIUM TUBERCULOSIS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 21(71), 40-43. SID. https://sid.ir/paper/49951/en

Vancouver: Copy

NADERI MOHAMMAD, NASERPOUR FARIVAR T., KOUHPAYEH H.R., OWEISI OSKOUIE H.. DRUG RESISTANCE OF ISOLATED STRAINS OF MYCOBACTERIUM TUBERCULOSIS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2004;21(71):40-43. Available from: https://sid.ir/paper/49951/en

IEEE: Copy

MOHAMMAD NADERI, T. NASERPOUR FARIVAR, H.R. KOUHPAYEH, and H. OWEISI OSKOUIE, “DRUG RESISTANCE OF ISOLATED STRAINS OF MYCOBACTERIUM TUBERCULOSIS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 21, no. 71, pp. 40–43, 2004, [Online]. Available: https://sid.ir/paper/49951/en

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