GENETIC LINKAGE ANALYSIS OF DFNB40 AND DFNB48 LOCI IN FAMILIES WITH AUTOSOMAL RECESSIVE NON-SYNDROMIC HEARING LOSS (ARNSHL) FROM WESTERN PROVINCES OF IRAN

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POURAHMADIYAN AZAM; TABATABAIEFAR MOHAMMAD AMIN; REIISI SOMAYEH; ALIPOUR PARIA; Fattahi Najmeh; HASHEMZADEH CHALESHTORI MORTEZA

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2016 | Volume:34 | Issue:374 Page(s): 214-220

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Title

GENETIC LINKAGE ANALYSIS OF DFNB40 AND DFNB48 LOCI IN FAMILIES WITH AUTOSOMAL RECESSIVE NON-SYNDROMIC HEARING LOSS (ARNSHL) FROM WESTERN PROVINCES OF IRAN

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Keywords

DFNB40 LOCUSQ1

DFNB48 LOCUSQ1

AUTOSOMAL RECESSIVE NON-SYNDROMIC HEARING LOSSQ1

Abstract

Background: Sensorineural hearing loss (SNHL) is the most common sensory disorder and 1 in every 500-1000 newborns is affected. Non-syndromic SNHL accounts for 70% of hereditary hearing loss and 80% of SNHL cases have an autosomal recessive mode of inheritance (ARNSHL). The Purpose of the recent study is genetic linkage analysis to determine the prevalence of DFNB40 and DFNB48 loci in studying families with ARNSHL from the western provinces of Iran.Methods: In this study, 60 families from 3 provinces of Iran involving Hamedan, Kohgiluyeh and Boyer-Ahmad and Chaharmahal and Bakhtiari with autosomal recessive non syndromic hearing loss were examined. The selected families in this study were consanguineous and had at least two patients. They also were negative for GJB2 mutations. Linkage analysis was performed by using 6 markers short tandem repeat (STR) for the DFNB40 LOCUS and 7 markers STR for the DFNB48 LOCUS.Findings: After examining different families, it was revealed that none of them showed linkage to the DFNB40 and DFNB48 loci.Conclusion: The recent study suggests that DFNB40 and DFNB48 loci might not play an important role in causing hearing loss in the mentioned provinces. However, further studies are necessary to determine more precisely the role of these loci in the Iranian population.

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APA: Copy

POURAHMADIYAN, AZAM, TABATABAIEFAR, MOHAMMAD AMIN, REIISI, SOMAYEH, ALIPOUR, PARIA, Fattahi, Najmeh, & HASHEMZADEH CHALESHTORI, MORTEZA. (2016). GENETIC LINKAGE ANALYSIS OF DFNB40 AND DFNB48 LOCI IN FAMILIES WITH AUTOSOMAL RECESSIVE NON-SYNDROMIC HEARING LOSS (ARNSHL) FROM WESTERN PROVINCES OF IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(374), 214-220. SID. https://sid.ir/paper/50012/en

Vancouver: Copy

POURAHMADIYAN AZAM, TABATABAIEFAR MOHAMMAD AMIN, REIISI SOMAYEH, ALIPOUR PARIA, Fattahi Najmeh, HASHEMZADEH CHALESHTORI MORTEZA. GENETIC LINKAGE ANALYSIS OF DFNB40 AND DFNB48 LOCI IN FAMILIES WITH AUTOSOMAL RECESSIVE NON-SYNDROMIC HEARING LOSS (ARNSHL) FROM WESTERN PROVINCES OF IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;34(374):214-220. Available from: https://sid.ir/paper/50012/en

IEEE: Copy

AZAM POURAHMADIYAN, MOHAMMAD AMIN TABATABAIEFAR, SOMAYEH REIISI, PARIA ALIPOUR, Najmeh Fattahi, and MORTEZA HASHEMZADEH CHALESHTORI, “GENETIC LINKAGE ANALYSIS OF DFNB40 AND DFNB48 LOCI IN FAMILIES WITH AUTOSOMAL RECESSIVE NON-SYNDROMIC HEARING LOSS (ARNSHL) FROM WESTERN PROVINCES OF IRAN,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 374, pp. 214–220, 2016, [Online]. Available: https://sid.ir/paper/50012/en

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