GENETIC LINKAGE ANALYSIS OF THE DFNB21 LOCUS IN AUTOSOMAL RECESSIVE HEARING LOSS IN LARGE FAMILIES FROM KHUZESTAN PROVINCE

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KHOSROFAR MAHTAB; POURREZA MOHAMMAD REZA; ASGHARZADEH SAMIRA; TAHMASEBI PARISA; ALI ASGARI ELAHE; GHASEMIKHAH REZA; SAKI NADER; MOHAMMADI ASL JAVAD; HASHEMZADEH CHALESHTORI MORTEZA; TABATABAIEFAR MOHAMMAD AMIN

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2017 | Volume:20 | Issue:3 (120) Page(s): 31-38

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Title

GENETIC LINKAGE ANALYSIS OF THE DFNB21 LOCUS IN AUTOSOMAL RECESSIVE HEARING LOSS IN LARGE FAMILIES FROM KHUZESTAN PROVINCE

Author(s)

Keywords

AUTOSOMAL RECESSIVE NON-SYNDROMIC HEARING LOSSQ1

DFNB21 LOCUSQ1

GENETIC LINKAGEQ1

Abstract

Background: Hearing loss (HL) is the most common congenital defect in humans. One or two in thousand newborn babies have prelingual hearing loss. AUTOSOMAL RECESSIVE NON-SYNDROMIC HEARING LOSS (ARNSHL) is the most common form of hereditary deafness. Hearing loss is more common in the developing countries which is due to genetic and environmental (cultural -health factors) reasons. HL has a wide range of clinical demonstrations including: congenital or late onset, conductive or sensoryneural, syndromic or non-syndromic hearing loss. The goal of this project is to determine the portion of the DFNB21 (TECTA) in ARNSHL in families with negative GJB2 gene in Khuzestan province.Materials and Methods: We studied 21 families with ARNSHL with at least 4 patients and negative forGJB2 mutations from Khuzestan province. GENETIC LINKAGE analysis was performed using STR markers linked to DFNB21 LOCUS.Results: Following GENETIC LINKAGE analysis and haplotyping, out of 21 families with ARNSHL, one family showed linkage to the DFNB21 (TECTA) locus.Conclusion: The results of this project confirm other studies in Iran and give insight into the most common loci causing ARNSHL in Iran which could be helpful in research and clinic.

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References

GENETIC LINKAGE ANALYSIS OF 15 DFNB LOCI IN A GROUP OF IRANIAN FAMILIES WITH AUTOSOMAL RECESSIVE HEARING LOSS

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APA: Copy

KHOSROFAR, MAHTAB, POURREZA, MOHAMMAD REZA, ASGHARZADEH, SAMIRA, TAHMASEBI, PARISA, ALI ASGARI, ELAHE, GHASEMIKHAH, REZA, SAKI, NADER, MOHAMMADI ASL, JAVAD, HASHEMZADEH CHALESHTORI, MORTEZA, & TABATABAIEFAR, MOHAMMAD AMIN. (2017). GENETIC LINKAGE ANALYSIS OF THE DFNB21 LOCUS IN AUTOSOMAL RECESSIVE HEARING LOSS IN LARGE FAMILIES FROM KHUZESTAN PROVINCE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(3 (120)), 31-38. SID. https://sid.ir/paper/69782/en

Vancouver: Copy

KHOSROFAR MAHTAB, POURREZA MOHAMMAD REZA, ASGHARZADEH SAMIRA, TAHMASEBI PARISA, ALI ASGARI ELAHE, GHASEMIKHAH REZA, SAKI NADER, MOHAMMADI ASL JAVAD, HASHEMZADEH CHALESHTORI MORTEZA, TABATABAIEFAR MOHAMMAD AMIN. GENETIC LINKAGE ANALYSIS OF THE DFNB21 LOCUS IN AUTOSOMAL RECESSIVE HEARING LOSS IN LARGE FAMILIES FROM KHUZESTAN PROVINCE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(3 (120)):31-38. Available from: https://sid.ir/paper/69782/en

IEEE: Copy

MAHTAB KHOSROFAR, MOHAMMAD REZA POURREZA, SAMIRA ASGHARZADEH, PARISA TAHMASEBI, ELAHE ALI ASGARI, REZA GHASEMIKHAH, NADER SAKI, JAVAD MOHAMMADI ASL, MORTEZA HASHEMZADEH CHALESHTORI, and MOHAMMAD AMIN TABATABAIEFAR, “GENETIC LINKAGE ANALYSIS OF THE DFNB21 LOCUS IN AUTOSOMAL RECESSIVE HEARING LOSS IN LARGE FAMILIES FROM KHUZESTAN PROVINCE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 3 (120), pp. 31–38, 2017, [Online]. Available: https://sid.ir/paper/69782/en

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