THE ROLE OF MATERNAL TSH RECEPTOR BLOCKING ANTIBODY IN THE ETIOLOGY OF CONGENITAL HYPOTHYROIDISM IN ISFAHAN

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SALEHI ABARI SHIMA; HASHEMIPOUR MAHIN; HAGHJOOY JAVANMARD SHAGHAYEGH; ESMAILL NAFISEH; AMINI MASOUD; KELISHADI ROYA; HASANZADEH AKBAR

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Journal: Journal of Isfahan Medical School Year:2011 | Volume:29 | Issue:137 Page(s): 537-545

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Title

THE ROLE OF MATERNAL TSH RECEPTOR BLOCKING ANTIBODY IN THE ETIOLOGY OF CONGENITAL HYPOTHYROIDISM IN ISFAHAN

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Keywords

CONGENITAL HYPOTHYROIDISMQ2

TSH RECEPTOR BLOCKING ANTIBODYQ2

ETIOLOGYQ3

Abstract

Background: Considering the role of maternal TSH receptor blocking Ab (TRAb) in the etioligy of CONGENITAL HYPOTHYROIDISM, the aim of this research was to determine its role among CONGENITAL HYPOTHYROIDISM (CH) in Isfahan.Methods: In this case control study, neonates with CH and their mothers and a group of healthy neonates and their mothers selected as case and control group, respectively. Venous blood samples obtained for the measurement of TRAb. The TSH of mothers was measured also. The prevalence of positive TRAb and the level of TSH were compared between studied groups.Findings: 50 neonates with CH and their mothers and 150 healthy neonates and their mothers studied in case and control groups, respectively. The prevalence of positive TRAb in neonates with CH and their mothers were higher than control group (P<0.05). There was significant relationship between the TRAb and occurrence of CONGENITAL HYPOTHYROIDISM (P<0.05).Conclusion: It seems that autoimmunity has an important role in the ETIOLOGY of CONGENITAL HYPOTHYROIDISM in Isfahan. In order to obtain more conclusive results in these field further studies to determine its role in the ETIOLOGY of permanent and transient CONGENITAL HYPOTHYROIDISM in accordance with studying other autoantibodies is recommended.

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APA: Copy

SALEHI ABARI, SHIMA, HASHEMIPOUR, MAHIN, HAGHJOOY JAVANMARD, SHAGHAYEGH, ESMAILL, NAFISEH, AMINI, MASOUD, KELISHADI, ROYA, & HASANZADEH, AKBAR. (2011). THE ROLE OF MATERNAL TSH RECEPTOR BLOCKING ANTIBODY IN THE ETIOLOGY OF CONGENITAL HYPOTHYROIDISM IN ISFAHAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 29(137), 537-545. SID. https://sid.ir/paper/50152/en

Vancouver: Copy

SALEHI ABARI SHIMA, HASHEMIPOUR MAHIN, HAGHJOOY JAVANMARD SHAGHAYEGH, ESMAILL NAFISEH, AMINI MASOUD, KELISHADI ROYA, HASANZADEH AKBAR. THE ROLE OF MATERNAL TSH RECEPTOR BLOCKING ANTIBODY IN THE ETIOLOGY OF CONGENITAL HYPOTHYROIDISM IN ISFAHAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2011;29(137):537-545. Available from: https://sid.ir/paper/50152/en

IEEE: Copy

SHIMA SALEHI ABARI, MAHIN HASHEMIPOUR, SHAGHAYEGH HAGHJOOY JAVANMARD, NAFISEH ESMAILL, MASOUD AMINI, ROYA KELISHADI, and AKBAR HASANZADEH, “THE ROLE OF MATERNAL TSH RECEPTOR BLOCKING ANTIBODY IN THE ETIOLOGY OF CONGENITAL HYPOTHYROIDISM IN ISFAHAN,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 29, no. 137, pp. 537–545, 2011, [Online]. Available: https://sid.ir/paper/50152/en

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