A CYTOGENIC STUDY OF BURKITT'S LYMPHOMA NAMALWA, RAJI, AND DAUDI CELL LINES

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SALEHI MANSOUR; SALEHI R.; BEHDADIPOUR Z.A.A.

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Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2005 | Volume:23 | Issue:78 Page(s): 49-56

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Title

A CYTOGENIC STUDY OF BURKITT'S LYMPHOMA NAMALWA, RAJI, AND DAUDI CELL LINES

Author(s)

SALEHI MANSOUR | SALEHI R. | BEHDADIPOUR Z.A.A. | Issue Writer Certificate

Keywords

BURKITT'S LYMPHOMAQ4

CANCER CYTOGENETICSQ4

DAUDIQ4

RAJIQ4

NAMALWAQ4

CHROMOSOME ABNORMALITIESQ3

Abstract

Introduction: Since 1960 and description of the Philadelphia chromosome, the association of specific structural and numerical CHROMOSOME ABNORMALITIES with certain types of malignancies has been appreciated. Therefore, the study of lymphoma cells lines may provide useful information about the cytogenetic evolution taking place during the establishment of the cell lines. Methods: The cell lines were cultured, harvested, resuspended in hypotonic solution and fixed. After trypsin treatment, the slides were stained using Leishman's method. The observed chromosomal abnormalities were then reported using ISCN 1995. In some cases, results of G-bandings were confirmed by FISH. In these cases mostly PCR amplified band-specific fluorescent-labeled probes, and for some abnormalities chromosome arm painting (CAP) probes were used. Results: Overall, analysis of cell lines demonstrated that the chromosome number of the majority of the cells was 46 in DAUDI and RAJI; this number for 45 for NAMALWA. The most common chromosome abnormality detected in all cells analyzed was t (8:14) with classical breakpoints (q24; q32), but many other abnormalities were also detected, such as additional material on the short arm of chromosome 11 (Daudi), additional material on the q35 of ch 4 (Raji) and an HSR attached to the long arm of one of the ch 1q (Namalwa) among others. Discussion: Our results demonstrated some well characterized CHROMOSOME ABNORMALITIES and also some variations in both the numerical and structural chromosomal abnormalities from those reported in other studies. Some of these CHROMOSOME ABNORMALITIES also have reported from BURKITT'S LYMPHOMA patents. Therefore characterizing these abnormalities might be of great importance in understanding the progression of the disease.

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APA: Copy

SALEHI, MANSOUR, SALEHI, R., & BEHDADIPOUR, Z.A.A.. (2005). A CYTOGENIC STUDY OF BURKITT'S LYMPHOMA NAMALWA, RAJI, AND DAUDI CELL LINES. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 23(78), 49-56. SID. https://sid.ir/paper/50249/en

Vancouver: Copy

SALEHI MANSOUR, SALEHI R., BEHDADIPOUR Z.A.A.. A CYTOGENIC STUDY OF BURKITT'S LYMPHOMA NAMALWA, RAJI, AND DAUDI CELL LINES. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2005;23(78):49-56. Available from: https://sid.ir/paper/50249/en

IEEE: Copy

MANSOUR SALEHI, R. SALEHI, and Z.A.A. BEHDADIPOUR, “A CYTOGENIC STUDY OF BURKITT'S LYMPHOMA NAMALWA, RAJI, AND DAUDI CELL LINES,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 23, no. 78, pp. 49–56, 2005, [Online]. Available: https://sid.ir/paper/50249/en

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