EFFECT OF ERYTHROPOIETIN (RECOMBINANT) IN DECREASING THE LEVEL OF HLA ANTIBODIES IN THE SERA OF PATIENTS AWAITING KIDNEY TRANSPLANTATION

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GHARAVI MANOUCHEHR; ADIB M.; AJOUDANI T.S.

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2001 | Volume:18 | Issue:60 Page(s): 59-64

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Information Journal Paper

Title

EFFECT OF ERYTHROPOIETIN (RECOMBINANT) IN DECREASING THE LEVEL OF HLA ANTIBODIES IN THE SERA OF PATIENTS AWAITING KIDNEY TRANSPLANTATION

Author(s)

GHARAVI MANOUCHEHR | ADIB M. | AJOUDANI T.S. | Issue Writer Certificate

Keywords

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Abstract

To determine the effect of rHuEPO therapy on 11sensitizedpatientson dialysis, we measured the level of HLA (human leukocyte antigen) antibodies (percentage panel reactive antibody or %PRA) before and after 13 ± 2 months of rHuEPO therapy.A control group of 11 patients matched for gender, age, duration of dialysis, previous blood transfusions and sensitization status were also included in this study. The control group did not recieve the drug during this time. The percent of panel reactive antibody (%PRA) was at least %25 in all patiens in the begining of study. The level of HLA antibodies were determined using the microlymphocytotoxicity method of NIH (national institute of health) and twenty different lymphocyte panel cells.After 13±2 months of using rHuEPO, in the case group the mean of %PRA declined ramatically from %54.09 to %10.9 and 5 of them were succesfully transplanted while in the control group the changes of mean PRA was only %1.8 during a comparable time interval (P<0.01).These data indicate that in sensitized dialysis patients, rHuEPO may lead to decreased sensitization. The decrease of HLA antibodies in rHuEPO treated patients may be the result of reduced administration of blood transfusions, and also direct effect of the drug on the immune reactivity.

Cites

THE EFFECT OF RECOMBINANT HUMAN ERYTHROPOIETIN ON THE REDUCTION OF ANTI-HLA ANTIBODY TITER IN SENSITIZED RATS

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APA: Copy

GHARAVI, MANOUCHEHR, ADIB, M., & AJOUDANI, T.S.. (2001). EFFECT OF ERYTHROPOIETIN (RECOMBINANT) IN DECREASING THE LEVEL OF HLA ANTIBODIES IN THE SERA OF PATIENTS AWAITING KIDNEY TRANSPLANTATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 18(60), 59-64. SID. https://sid.ir/paper/50544/en

Vancouver: Copy

GHARAVI MANOUCHEHR, ADIB M., AJOUDANI T.S.. EFFECT OF ERYTHROPOIETIN (RECOMBINANT) IN DECREASING THE LEVEL OF HLA ANTIBODIES IN THE SERA OF PATIENTS AWAITING KIDNEY TRANSPLANTATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2001;18(60):59-64. Available from: https://sid.ir/paper/50544/en

IEEE: Copy

MANOUCHEHR GHARAVI, M. ADIB, and T.S. AJOUDANI, “EFFECT OF ERYTHROPOIETIN (RECOMBINANT) IN DECREASING THE LEVEL OF HLA ANTIBODIES IN THE SERA OF PATIENTS AWAITING KIDNEY TRANSPLANTATION,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 18, no. 60, pp. 59–64, 2001, [Online]. Available: https://sid.ir/paper/50544/en

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