THE EFFECT OF RECOMBINANT HUMAN ERYTHROPOIETIN ON THE REDUCTION OF ANTI-HLA ANTIBODY TITER IN SENSITIZED RATS

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VAHDATI A.; AFROUZ T.; KASHFI SH.; ADIB M.

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Journal: Physiology and Pharmacology Year:2005 | Volume:8 | Issue:2 Page(s): 137-142

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Information Journal Paper

Title

THE EFFECT OF RECOMBINANT HUMAN ERYTHROPOIETIN ON THE REDUCTION OF ANTI-HLA ANTIBODY TITER IN SENSITIZED RATS

Author(s)

VAHDATI A. | AFROUZ T. | KASHFI SH. | ADIB M. | Issue Writer Certificate

Keywords

RECOMBINANT HUMAN ERYTHROPOIETINQ4

ANTIBODYQ3

LYMPHOCYTEQ3

Abstract

Erythropoietin was first introduced as a factor of RBC proliferation and differentiation. Since the use of recombinant human eryrthropoietin (rHuEPO) in the treatment of anemic patients has increased in recent years, therefore, much attention has been focused on its effects on the immune system. Therefore, in the present study anti-HLA ANTIBODY titer changes in three groups of sensitized rats (20 and 100 IU/Kg) were evaluated following administration of two doses of rHuEPO. For this purpose, rats were presensitized with HLA antigens of human Iymphocytes. In this respect, RHuEPO injected subcutaneously two times a week for a period of six weeks. ANTIBODY titers were measured by microlymphocytotoxicity method. The results showed that rHuEPo significantly decreases anti-HLA ANTIBODY titer. This decrease could be attributed to a reduction in the number or activity of T and B LYMPHOCYTEs. This effect may also be interpreted by different dosages of the drug, treatment duration, and/or the level of previous sensitization of rats.

Cites

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References

EFFECT OF ERYTHROPOIETIN (RECOMBINANT) IN DECREASING THE LEVEL OF HLA ANTIBODIES IN THE SERA OF PATIENTS AWAITING KIDNEY TRANSPLANTATION

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APA: Copy

VAHDATI, A., AFROUZ, T., KASHFI, SH., & ADIB, M.. (2005). THE EFFECT OF RECOMBINANT HUMAN ERYTHROPOIETIN ON THE REDUCTION OF ANTI-HLA ANTIBODY TITER IN SENSITIZED RATS . PHYSIOLOGY AND PHARMACOLOGY, 8(2), 137-142. SID. https://sid.ir/paper/75113/en

Vancouver: Copy

VAHDATI A., AFROUZ T., KASHFI SH., ADIB M.. THE EFFECT OF RECOMBINANT HUMAN ERYTHROPOIETIN ON THE REDUCTION OF ANTI-HLA ANTIBODY TITER IN SENSITIZED RATS . PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2005;8(2):137-142. Available from: https://sid.ir/paper/75113/en

IEEE: Copy

A. VAHDATI, T. AFROUZ, SH. KASHFI, and M. ADIB, “THE EFFECT OF RECOMBINANT HUMAN ERYTHROPOIETIN ON THE REDUCTION OF ANTI-HLA ANTIBODY TITER IN SENSITIZED RATS ,” PHYSIOLOGY AND PHARMACOLOGY, vol. 8, no. 2, pp. 137–142, 2005, [Online]. Available: https://sid.ir/paper/75113/en

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