THE EFFECT OF CYCLOPHOSPHAMIDE ON TLR2 GENE EXPRESSION IN BALB/C MICE WITH SYSTEMIC CANDIDIASIS

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Morovati Hamid; TOLOUEI SEPIDEH; DEHGHAN PARVIN; BARADARAN BEHZAD; MOHAMMADIFARD AMIR; YOUSEFI ZAHRA

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Journal: Journal of Isfahan Medical School Year:2016 | Volume:34 | Issue:389 Page(s): 771-776

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Title

THE EFFECT OF CYCLOPHOSPHAMIDE ON TLR2 GENE EXPRESSION IN BALB/C MICE WITH SYSTEMIC CANDIDIASIS

Author(s)

Keywords

SYSTEMIC CANDIDIASISQ1

TOLL LIKE RECEPTOR-2 (TLR2)Q1

CYCLOPHOSPHAMIDEQ2

NEOTROPENIAQ2

BALB/CQ3

Abstract

Background: Toll like receptor-2 (TLR2) plays an important role in the process of detection and launching the immune response against Candida albicans. CYCLOPHOSPHAMIDE is one of the most widely used chemotherapy drugs, which causes severe neutropenia and suppression of the immune system. In this study BALB/C mice were infected to disseminated candidiasis and neutropenia and expression of TLR2 gene was measured in whole blood samples of each mice.Methods: Twenty-eight mice were divided into 4 groups and injected with CYCLOPHOSPHAMIDE and C. albicans.Blood samples were used for RNA extraction and cDNA synthesis, and expression of TLR2 gene was measured by real-time polymerase chain reaction (Real-time PCR). Statistical analysis was performed using Kruskal-Wallis and 2-DDCT method.Findings: Gene expression was increased in the group receiving Candida albicans and also in group receiving both CYCLOPHOSPHAMIDE and Candida albicans but decreased in the group just receiving CYCLOPHOSPHAMIDE.Conclusion: There was no significant difference between the control group and experimental groups for TLR2 gene expression (P=0.478). However, the results of this study can be regarding in selecting TLR2 or its receptor as a therapeutic target with monoclonal antibodies or gene therapy techniques.

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APA: Copy

Morovati, Hamid, TOLOUEI, SEPIDEH, DEHGHAN, PARVIN, BARADARAN, BEHZAD, MOHAMMADIFARD, AMIR, & YOUSEFI, ZAHRA. (2016). THE EFFECT OF CYCLOPHOSPHAMIDE ON TLR2 GENE EXPRESSION IN BALB/C MICE WITH SYSTEMIC CANDIDIASIS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(389), 771-776. SID. https://sid.ir/paper/50556/en

Vancouver: Copy

Morovati Hamid, TOLOUEI SEPIDEH, DEHGHAN PARVIN, BARADARAN BEHZAD, MOHAMMADIFARD AMIR, YOUSEFI ZAHRA. THE EFFECT OF CYCLOPHOSPHAMIDE ON TLR2 GENE EXPRESSION IN BALB/C MICE WITH SYSTEMIC CANDIDIASIS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;34(389):771-776. Available from: https://sid.ir/paper/50556/en

IEEE: Copy

Hamid Morovati, SEPIDEH TOLOUEI, PARVIN DEHGHAN, BEHZAD BARADARAN, AMIR MOHAMMADIFARD, and ZAHRA YOUSEFI, “THE EFFECT OF CYCLOPHOSPHAMIDE ON TLR2 GENE EXPRESSION IN BALB/C MICE WITH SYSTEMIC CANDIDIASIS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 389, pp. 771–776, 2016, [Online]. Available: https://sid.ir/paper/50556/en

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