COMPARISON BETWEEN EFFICACY OF CORTICOSTEROID AND PROMETHAZINE IN TREATMENT OF HYPEREMESIS GRAVIDARUM

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KAREGAR F.; MARDANIAN F.

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2004 | Volume:22 | Issue:72 Page(s): 36-39

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Title

COMPARISON BETWEEN EFFICACY OF CORTICOSTEROID AND PROMETHAZINE IN TREATMENT OF HYPEREMESIS GRAVIDARUM

Author(s)

KAREGAR F. | MARDANIAN F. | Issue Writer Certificate

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Abstract

Introduction. Nausea and vomiting in pregnancy are common, that is a heat-sink problem for pregnant women. It cause inbalance of water and electrolytes, weight loss, malnutrition and frequent admision pregnant women in hospital The porpose of this study is to comparision between efficacy of corticosteroid and promethazine in treatment of hyperemesis gravidarum.Methods. This study performed in sixty pregnant women with gestational age 7-20 weeks. In two groups with severe hyperemesis (numbers of vomiting>2 times per day), none tolerance food intake, ketonuria > 1 positive or weight loss. Corticosteroid group recieved tablet prednisolone, 20 mg daily in two divided dose, if vominting was more than 2 times per day, after 48 hours, they received hydrocortizone, 200 mg daily IV in two divided dose.Promethazine group received tablet promethazine, 25 mg BID (two divided dose daily), if vomiting was more than 2 times per day after 48 hours, they recieved amp promethazine 25 mg Bid, Iv. The period of treatment was four days: Informations were gathered with checklist and analysed.Results. There was no significant difference between two groups (frequency of vomiting, well being, severity of nausea and tolerance of food intake scoring) at admission. In promethazine and corticosteroid group: 30% and 56.7% responsed to oral treatment, 70% and 43.3% were changed to intravenous therapy, 46.9% and 84.6% responsed to intravenous therapy. Therefore 60% and 93.3% responsed and reduced frequency of vomiting. (p<0.05)Discussion. Short coarse of corticosteroid is more effective than promethazine for treatment of hyperemesis gravidarum in first step and effective alternative therapy for refractory cases.

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APA: Copy

KAREGAR, F., & MARDANIAN, F.. (2004). COMPARISON BETWEEN EFFICACY OF CORTICOSTEROID AND PROMETHAZINE IN TREATMENT OF HYPEREMESIS GRAVIDARUM. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 22(72), 36-39. SID. https://sid.ir/paper/50693/en

Vancouver: Copy

KAREGAR F., MARDANIAN F.. COMPARISON BETWEEN EFFICACY OF CORTICOSTEROID AND PROMETHAZINE IN TREATMENT OF HYPEREMESIS GRAVIDARUM. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2004;22(72):36-39. Available from: https://sid.ir/paper/50693/en

IEEE: Copy

F. KAREGAR, and F. MARDANIAN, “COMPARISON BETWEEN EFFICACY OF CORTICOSTEROID AND PROMETHAZINE IN TREATMENT OF HYPEREMESIS GRAVIDARUM,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 22, no. 72, pp. 36–39, 2004, [Online]. Available: https://sid.ir/paper/50693/en

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