ALLOPOURINOL EFFECT ON REDUCING PROTEINURIA IN DIABETIC RETINOPATHY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOMENI ALI; SHAHIDI SHAHRZAD; SEIRAFIAN SHIVA; TAHERI SHAHRAM; KHEIRI SOLEIMAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2010 | Volume:28 | Issue:107 Page(s): 271-278

Download Full-Text

Persian Verion

View:

2,707

Download:

Cites:

Information Journal Paper

Title

ALLOPOURINOL EFFECT ON REDUCING PROTEINURIA IN DIABETIC RETINOPATHY

Author(s)

Keywords

DIABETIC NEPHROPATHYQ2

URIC ACIDQ2

ALLOPURINOLQ3

PROTEINURIAQ3

Abstract

Background: DIABETIC NEPHROPATHY is the most prevalent cause of end stage renal disease (ESRD). Besides, factors such as angiotensin-II, cytokines, and vascular endothelial growth factor (VEGF), URIC ACID may play a role as the underlying cause of DIABETIC NEPHROPATHY. Therefore, decreasing serum level of URIC ACID can be effective in treatment of DIABETIC NEPHROPATHY.Methods: This was a double-blinded, randomized, clinical trial in which 40 patients with type 2 diabetes mellitus (DM) and DIABETIC NEPHROPATHY with PROTEINURIA (at least 500 mg/24h) and serum creatinine (Cr) level<3 mg/dl were divided into two groups of 20. Case group received ALLOPURINOL (100 mg/day) and control group received placebo for four months. Administration of antihypertensive and renoprotective drugs (angiotensin converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARBs)) continued for both groups, without changes in dosage.Findings: Each group consisted of 9 men and 11 women. There were no difference between two groups, regarding age, body mass index (BMI), duration of diabetes, systolic and diastolic blood pressure, fasting blood sugar, serum blood urine nitrogen (BUN), serum creatinine (Cr), serum potassium, and urine volume (P>0.05). Serum level of URIC ACID and 24 hour urine protein were significantly lower in control group, after four months of receiving ALLOPURINOL, compared with control group (P<0.05).Conclusion: Low dose ALLOPURINOL (100mg/day) reduces severity of PROTEINURIA after four months of taking, which is probably due to decreasing the serum level of URIC ACID. So, ALLOPURINOL can be administered as an adjuvant, cheap, and low side-effect therapy for patients with DIABETIC NEPHROPATHY.

Cites

THE COMPARATIVE STUDY OF MARKEDNESS IN PERSIAN AND ENGLISH BASED ON SFG

References

No record.

Cite

APA: Copy

MOMENI, ALI, SHAHIDI, SHAHRZAD, SEIRAFIAN, SHIVA, TAHERI, SHAHRAM, & KHEIRI, SOLEIMAN. (2010). ALLOPOURINOL EFFECT ON REDUCING PROTEINURIA IN DIABETIC RETINOPATHY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 28(107), 271-278. SID. https://sid.ir/paper/50856/en

Vancouver: Copy

MOMENI ALI, SHAHIDI SHAHRZAD, SEIRAFIAN SHIVA, TAHERI SHAHRAM, KHEIRI SOLEIMAN. ALLOPOURINOL EFFECT ON REDUCING PROTEINURIA IN DIABETIC RETINOPATHY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2010;28(107):271-278. Available from: https://sid.ir/paper/50856/en

IEEE: Copy

ALI MOMENI, SHAHRZAD SHAHIDI, SHIVA SEIRAFIAN, SHAHRAM TAHERI, and SOLEIMAN KHEIRI, “ALLOPOURINOL EFFECT ON REDUCING PROTEINURIA IN DIABETIC RETINOPATHY,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 28, no. 107, pp. 271–278, 2010, [Online]. Available: https://sid.ir/paper/50856/en

Related Journal Papers