ROLE OF GW0742 A PPARβ/δ AGONIST ON CORONARY ANGIOGENESIS IN CONTROL AND DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SALEHI ENSIEH; KHAZAEI MAJID; RASHIDI BAHMAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download Full-Text

Persian Verion

View:

915

Download:

Cites:

Information Journal Paper

Title

ROLE OF GW0742 A PPARβ/δ AGONIST ON CORONARY ANGIOGENESIS IN CONTROL AND DIABETIC RATS

Author(s)

SALEHI ENSIEH | KHAZAEI MAJID | RASHIDI BAHMAN | Issue Writer Certificate

Keywords

DIABETESQ2

ANGIOGENESISQ2

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORSQ2

Abstract

Background: Peroxisome proliferator activated receptors (PPARs) are ligand activated transcription factors, comprising of three isoforms in human: PPARb/d, PPARg and PPARa. Since PPARs affect on cytokines and growth factors, it is suggested that PPARs may be regulated ANGIOGENESIS process. In this study, we investigated the hypothesis that activation of PPARb/d by GW0742 can restore coronary ANGIOGENESIS in diabetic and control rats.Methods: Twenty-four male rats were randomly divided into four groups. For induction of DIABETES we used streptozotocin (50 mg/kg). The groups were as follows: group 1: control rats were given placebo, group 2: control rats were given GW0742 (1 mg/kg/day) subcutaneously, group 3: diabetic rats were given placebo and group 4: diabetic rats were given GW0742 (1 mg/kg/day) subcutaneously.After 21 days capillary density was evaluated in cardiac muscle by immunohistochemistry.Findings: The mean capillary density in cardiac muscles of diabetic rats were lower than control (P=0.08). GW0742 administration could restore capillary density of the heart in diabetic rats (215.82± 11.3 versus121.71 ± 13.32 number of capillaries per mm2) while could not alter capillary density in control rats (156.3± 8.97 versus 153.78 ± 11.08 number of capillaries per mm2).Conclusion: this study showed that DIABETES is associated by reduced capillary density in the heart.PPARb/d activation by GW0742 could restore coronary ANGIOGENESIS in diabetic rats while did not change ANGIOGENESIS in non diabetic rats.

Cites

No record.

References

No record.

Cite

APA: Copy

SALEHI, ENSIEH, KHAZAEI, MAJID, & RASHIDI, BAHMAN. (2011). ROLE OF GW0742 A PPARβ/δ AGONIST ON CORONARY ANGIOGENESIS IN CONTROL AND DIABETIC RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 29(145), 861-868. SID. https://sid.ir/paper/51005/en

Vancouver: Copy

SALEHI ENSIEH, KHAZAEI MAJID, RASHIDI BAHMAN. ROLE OF GW0742 A PPARβ/δ AGONIST ON CORONARY ANGIOGENESIS IN CONTROL AND DIABETIC RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2011;29(145):861-868. Available from: https://sid.ir/paper/51005/en

IEEE: Copy

ENSIEH SALEHI, MAJID KHAZAEI, and BAHMAN RASHIDI, “ROLE OF GW0742 A PPARβ/δ AGONIST ON CORONARY ANGIOGENESIS IN CONTROL AND DIABETIC RATS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 29, no. 145, pp. 861–868, 2011, [Online]. Available: https://sid.ir/paper/51005/en

Related Journal Papers