THE EFFECT OF TOPICAL AVASTIN IN THE SUCCESS RATE OF DACRYOCYSTORHINOSTOMY

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SALEHI ALI; ZANDI ALIREZA; ZANDI ATHAR; ABTAHI SEYED MOHAMMAD ALI; SONBOLESTAN SEYED ALI

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2016 | Volume:34 | Issue:387 Page(s): 718-723

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Title

THE EFFECT OF TOPICAL AVASTIN IN THE SUCCESS RATE OF DACRYOCYSTORHINOSTOMY

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Keywords

AVASTINQ2

DACRYOCYSTORHINOSTOMYQ1

RECURRENCEQ2

Abstract

Background: Many factors are involved in the failure rate of DACRYOCYSTORHINOSTOMY (DCR) surgery as the standard treatment of nasolacrimal duct obstruction. There is however, a lot of evidence that bevacizumab (AVASTIN) with less side effects, has the same anti-fibrosis effects. In this study we evaluated the effect of this drug on the failure rate of DCR.Methods: 60 candidates for DCR were divided to two groups each one containing 30 patients. These 2 groups were matched by age and sex. We used AVASTIN eye-drops (5 mg/ml) every 6 hours in one group for 2 weeks in addition to other post-op routine treatments. The patients were evaluated for failure of DCR 2 weeks and 3 months after surgery.Findings: In the Avasin group no patient showed surgery failure. In the other group, 1 patient in 2 week and 2 patients in 3 months follow-up showed failure. However this difference between 2 groups was not statistically significant and maybe due to small sample size. (P=0.327, Fisher exact test).Conclusion: AVASTIN eye drop may lower the failure rate of DCR. This subject needs to be more evaluated in further studies.

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APA: Copy

SALEHI, ALI, ZANDI, ALIREZA, ZANDI, ATHAR, ABTAHI, SEYED MOHAMMAD ALI, & SONBOLESTAN, SEYED ALI. (2016). THE EFFECT OF TOPICAL AVASTIN IN THE SUCCESS RATE OF DACRYOCYSTORHINOSTOMY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(387), 718-723. SID. https://sid.ir/paper/51024/en

Vancouver: Copy

SALEHI ALI, ZANDI ALIREZA, ZANDI ATHAR, ABTAHI SEYED MOHAMMAD ALI, SONBOLESTAN SEYED ALI. THE EFFECT OF TOPICAL AVASTIN IN THE SUCCESS RATE OF DACRYOCYSTORHINOSTOMY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;34(387):718-723. Available from: https://sid.ir/paper/51024/en

IEEE: Copy

ALI SALEHI, ALIREZA ZANDI, ATHAR ZANDI, SEYED MOHAMMAD ALI ABTAHI, and SEYED ALI SONBOLESTAN, “THE EFFECT OF TOPICAL AVASTIN IN THE SUCCESS RATE OF DACRYOCYSTORHINOSTOMY,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 387, pp. 718–723, 2016, [Online]. Available: https://sid.ir/paper/51024/en

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