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Information Journal Paper

Title

THE ALOE VERA GEL IMPROVES STRUCTURAL DISORDERS IN THE BRAIN OF STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS

Pages

  235-242

Abstract

 Background: DIABETES MELLITUS can lead to structural disorders in the brain. ALOE VERA has antidiabetic, antioxidant, and neuroprotective effects. This study was designed to evaluate the effects of ALOE VERA gel on the morphometric changes in the brain of streptozotocin-induced diabetic RATS.Methods: 25 male Wistar RATS were randomly divided into 5 groups including: control (normal saline), diabetic (normal saline), ALOE VERA gel (400 mg/kg/day; gavage), diabetic+Aloe vera gel (400 mg/kg/day; gavage) and diabetic+Neutral Protamine Hagedorn (NPH) insulin (10 IU/kg/day; subcutaneous). Experimental diabetes was induced by streptozotocin injection (60 mg/kg; intraperitoneal). All groups treated for 8 weeks. At the end of treatment course, the RATS' brains were removed intact immediately after sacrifice for morphometric measuring by caliper. Histological brain sections were also prepared to assess morphometry of cerebral cortex and hippocampus via ammonium iron (III) sulfate staining.Findings: Diabetes induction reduced weight and dimensions of brain, and diameters of the hippocampus, and white and gray matter of cerebral cortex compared to the control group after 8 weeks (P<0.05); while treatment of diabetic RATS with ALOE VERA gel or insulin significantly decreased the structural alterations of the brain and improved the blood glucose level of diabetic RATS (P<0.05).Conclusion: The results showed that oral administration of ALOE VERA gel in diabetic RATS improves structural disorders of brain and ameliorates diabetes-induced hyperglycemia.

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    APA: Copy

    BAHRAMI TAPEHEBUR, MOHAMMAD, MAZAHERI, YAZDAN, KHAKSARY MAHABADY, MAHMOOD, FATEMI TABATABAEI, SEYED REZA, & TABANDEH, MOHAMMAD REZA. (2017). THE ALOE VERA GEL IMPROVES STRUCTURAL DISORDERS IN THE BRAIN OF STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(422), 235-242. SID. https://sid.ir/paper/51042/en

    Vancouver: Copy

    BAHRAMI TAPEHEBUR MOHAMMAD, MAZAHERI YAZDAN, KHAKSARY MAHABADY MAHMOOD, FATEMI TABATABAEI SEYED REZA, TABANDEH MOHAMMAD REZA. THE ALOE VERA GEL IMPROVES STRUCTURAL DISORDERS IN THE BRAIN OF STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2017;35(422):235-242. Available from: https://sid.ir/paper/51042/en

    IEEE: Copy

    MOHAMMAD BAHRAMI TAPEHEBUR, YAZDAN MAZAHERI, MAHMOOD KHAKSARY MAHABADY, SEYED REZA FATEMI TABATABAEI, and MOHAMMAD REZA TABANDEH, “THE ALOE VERA GEL IMPROVES STRUCTURAL DISORDERS IN THE BRAIN OF STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 35, no. 422, pp. 235–242, 2017, [Online]. Available: https://sid.ir/paper/51042/en

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