IN-VITRO STUDY OF HOMOCYSTEINE AND ASPIRIN EFFECTS ON COAGULATION AND CLOT PERMEABILITY

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ZAVAR REZA JAVAD; DANESH POUYA FAHIMEH; JALALI BEMANALI; SHAHMORADI HAMIDREZA

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Journal: Journal of Isfahan Medical School Year:2013 | Volume:31 | Issue:262 Page(s): 1932-1940

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Title

IN-VITRO STUDY OF HOMOCYSTEINE AND ASPIRIN EFFECTS ON COAGULATION AND CLOT PERMEABILITY

Author(s)

ZAVAR REZA JAVAD | DANESH POUYA FAHIMEH | JALALI BEMANALI | SHAHMORADI HAMIDREZA | Issue Writer Certificate

Keywords

HOMOCYSTEINEQ3

ASPIRINQ3

COAGULATIONQ2

PERMEABILITYQ2

Abstract

Background: Some studies suggest that increased homocystein in blood leads to alterations in COAGULATION; however, the precise mechanism is not clear. The aim of this study was to compare different concentrations of HOMOCYSTEINE and ASPIRIN on COAGULATION parameters and PERMEABILITY coefficient of clot in the plasma of healthy individuals in vitro.Methods: Different concentrations of HOMOCYSTEINE (50, 100, 200 μM) and ASPIRIN (1, 10, 100 mg/l) were added to the plasma citrate. They were incubated at 37°C for 24 hours. Then, COAGULATION parameters were analyzed by the turbidimetric procedure at 405 nm and PERMEABILITY coefficient of clot was determined. The independent samples t-test was utilized to compare the results.Findings: HOMOCYSTEINE at 200 mM with ASPIRIN 100 mg/l had significant changes in the total COAGULATION time (820.00±1.15 s), maximum COAGULATION velocity (0.232±0.003), the PERMEABILITY coefficient of clot [(1.108×10-6) ±0.151] compared to HOMOCYSTEINE at 200 mM [555.00±12.89, 0.258±0.008, (0.493×10-6)±0.038, respectively] (P<0.05). HOMOCYSTEINE at 200 mM with ASPIRIN 1 mg/l did not significantly change in either parameter (P>0.05). HOMOCYSTEINE at 100 mM with ASPIRIN 1 mg/l significantly changed only in the PERMEABILITY coefficient [(0.787×10-6) ±0.071] compared to HOMOCYSTEINE at 100 mM [(0.636×10-6) ±0.053] (P<0.05).Conclusion: ASPIRIN with the dose more than 1 mg/l had more effect on higher concentrations of HOMOCYSTEINE and delayed forming clot by impeding the COAGULATION. It increased clot PERMEABILITY, too.

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APA: Copy

ZAVAR REZA, JAVAD, DANESH POUYA, FAHIMEH, JALALI, BEMANALI, & SHAHMORADI, HAMIDREZA. (2013). IN-VITRO STUDY OF HOMOCYSTEINE AND ASPIRIN EFFECTS ON COAGULATION AND CLOT PERMEABILITY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(262), 1932-1940. SID. https://sid.ir/paper/51133/en

Vancouver: Copy

ZAVAR REZA JAVAD, DANESH POUYA FAHIMEH, JALALI BEMANALI, SHAHMORADI HAMIDREZA. IN-VITRO STUDY OF HOMOCYSTEINE AND ASPIRIN EFFECTS ON COAGULATION AND CLOT PERMEABILITY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(262):1932-1940. Available from: https://sid.ir/paper/51133/en

IEEE: Copy

JAVAD ZAVAR REZA, FAHIMEH DANESH POUYA, BEMANALI JALALI, and HAMIDREZA SHAHMORADI, “IN-VITRO STUDY OF HOMOCYSTEINE AND ASPIRIN EFFECTS ON COAGULATION AND CLOT PERMEABILITY,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 262, pp. 1932–1940, 2013, [Online]. Available: https://sid.ir/paper/51133/en

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