MULTIPLE IV IIMMUNOGLOBULIN THERAPY IN NEWBORNS WITH IMMUNE HEMOLYTIC JAUNDICE

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MAMOURI GH.A.; BOSKABADI H.; BABAEI HOMA; NASERI F.

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2006 | Volume:49 | Issue:93 Page(s): 287-292

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Title

MULTIPLE IV IIMMUNOGLOBULIN THERAPY IN NEWBORNS WITH IMMUNE HEMOLYTIC JAUNDICE

Author(s)

MAMOURI GH.A. | BOSKABADI H. | BABAEI HOMA | NASERI F. | Issue Writer Certificate

Keywords

INTRAVENOUS IMMUNOGLOBULINQ3

NEWBORNQ3

HEMOLYTIC JAUNDICEQ3

Abstract

Introduction: The Conventional treatment for neonatal immune hemolytic disease is, phototherapy and blood exchange transfusion. The aim of this study was to determine the efficasy of multiple dose of IVIG in reducing the need for exchange transfusion and phototherapy in HEMOLYTIC JAUNDICE of NEWBORN.Material and methods: The study was performed at NICU of Ghaem Hospital as a case –control study, over a period of one year (oct 2002-oct 2003). Patients with ABO and RH incompatibility, proven by significant hyperbilirubinemia (Bill>8mg/dl at 12hr of age), positive direct or indirect comb's, and no other Risk factors, like sepsis and G6PD deficiency or early familial icterus, were randomly assigned to receive either conventional intensive phototherapy alone or phototherapy with IVIG 0.5gr/kgevery 12hr for three times. Exchange transfusion was performed if billirubin exceded more than 20mg/dl.Results: A total of 34 NEWBORN infants were included in the study. There was no significant difference between two groups, with respect to birthweight, postnatal age, sex, bilirubin, hematocrit, or reticulocite count. The number of exchange transfusion, duration of phototherapy and hospitalization, were significantly lower in IVIg treatment group than control one. Adverse effects were not observed during MG treatment.Conclusion: IVIG therapy is a safe treatment for NEWBORNs with HEMOLYTIC JAUNDICE and Reduces exchange transfusion.

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APA: Copy

MAMOURI, GH.A., BOSKABADI, H., BABAEI, HOMA, & NASERI, F.. (2006). MULTIPLE IV IIMMUNOGLOBULIN THERAPY IN NEWBORNS WITH IMMUNE HEMOLYTIC JAUNDICE. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 49(93), 287-292. SID. https://sid.ir/paper/51639/en

Vancouver: Copy

MAMOURI GH.A., BOSKABADI H., BABAEI HOMA, NASERI F.. MULTIPLE IV IIMMUNOGLOBULIN THERAPY IN NEWBORNS WITH IMMUNE HEMOLYTIC JAUNDICE. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;49(93):287-292. Available from: https://sid.ir/paper/51639/en

IEEE: Copy

GH.A. MAMOURI, H. BOSKABADI, HOMA BABAEI, and F. NASERI, “MULTIPLE IV IIMMUNOGLOBULIN THERAPY IN NEWBORNS WITH IMMUNE HEMOLYTIC JAUNDICE,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 49, no. 93, pp. 287–292, 2006, [Online]. Available: https://sid.ir/paper/51639/en

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